New insights into RSK activation and hematopoietic cancer

被引：15

作者：

Cuadrado, Ana ^{[1
]}

Nebreda, Angel R. ^{[1
]}

机构：

[1] Spanish Natl Canc Ctr, E-28029 Madrid, Spain

来源：

CANCER CELL | 2007年 / 12卷 / 03期

关键词：

D O I：

10.1016/j.ccr.2007.08.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The tyrosine kinase receptor FGFR3 is thought to play a role in hematopoietic malignancies. A new study in this issue of Cancer Cell identifies the serine/threonine kinase RSK2 as a key substrate of FGFR3 in human t(4;14)-positive multiple myeloma (MM) cells. Constitutively active FGFR3 directly phosphorylates RSK2 on Tyr529, which primes RSK2 for activation by the kinases ERK1 and ERK2 (ERK1/2). In turn, RSK2 activity plays an important role in the survival of FGFR3-expressing MM cells.

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收藏

页码：187 / 189

页数：3

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