Synthesis of Diheterocyclic Compounds Based on Triazolyl Methoxy Phenylquinazolines via a One-Pot Four-Component-Click Reaction

被引：35

作者：

Dabiri, Minoo ^{[1
]}

Salehi, Peyman ^{[2
]}

Bahramnejad, Mahboobeh ^{[1
]}

Sherafat, Fatemeh ^{[1
]}

机构：

[1] Shahid Beheshti Univ, GC, Fac Sci, Dept Chem, Tehran 1983963113, Iran

[2] Shahid Beheshti Univ, GC, Dept Phytochem Med Plants & Drugs, Res Inst, Tehran 1983963113, Iran

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2010年 / 12卷 / 05期

关键词：

CLICK CHEMISTRY; MULTICOMPONENT; INHIBITORS; DISCOVERY; DNA;

D O I：

10.1021/cc100043z

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A facile and highly efficient method for one-pot four-component synthesis of triazolyl methoxy phenylquinazolines is described. A mixture of aromatic propargylated aldehydes, different azides, 2-aminobenzophenone derivatives, and ammonium acetate were condensed in the presence of catalytic amounts of acidic ionic liquid, 1-methylimidazolium trifluoroacetate, ([Hmim]TFA), and Cu(OAc)(2)/sodium ascorbate to afford the corresponding products in excellent yields. This methodology is highly efficient for structurally diverse azides.

引用

页码：638 / 642

页数：5

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