Identifying a low-risk group for parametrial involvement in microscopic Stage IB1 cervical cancer using criteria from ongoing studies and a new MRI criterion

被引:13
作者
Lee, Jung-Yun [1 ]
Youm, Jina [2 ]
Kim, Jae-Weon [2 ,3 ]
Cho, Jeong Yeon
Kim, Min A. [4 ]
Kim, Tae Hun [5 ]
Suh, Dong Hoon [6 ]
Lim, Myong Cheol [7 ,8 ]
Park, Noh Hyun [2 ]
Song, Yong-Sang [2 ]
机构
[1] Yonsei Univ, Coll Med, Inst Womens Med Life Sci, Dept Obstet & Gynecol, Seoul 120752, South Korea
[2] Seoul Natl Univ, Dept Obstet & Gynecol, Coll Med, Seoul 110744, South Korea
[3] Seoul Natl Univ, Coll Med, Dept Radiol, Seoul 110744, South Korea
[4] Seoul Natl Univ, Coll Med, Dept Pathol, Seoul 110744, South Korea
[5] Korea Canc Ctr, Dept Obstet & Gynecol, Seoul, South Korea
[6] Seoul Natl Univ, Bundang Hosp, Dept Obstet & Gynecol, Gyeonggi Di, South Korea
[7] Natl Canc Ctr, Ctr Uterine Canc, Goyang, Gyeonggi Do, South Korea
[8] Natl Canc Ctr, Gynecol Canc Branch, Goyang, Gyeonggi Do, South Korea
关键词
Cervical cancer; Microscopic IB1; Parametrial involvement; Less radical surgery; Magnetic resonance imaging; LESS RADICAL SURGERY; IDENTIFICATION; HYSTERECTOMY; PARAMETRECTOMY; TRACHELECTOMY; CONIZATION;
D O I
10.1186/s12885-015-1184-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: There are currently three ongoing studies on less radical surgery in cervical cancer: ConCerv, GOG-278, and SHAPE. The aim of this study was to evaluate the performance of the criteria used in ongoing studies retrospectively and suggest a new, simplified criterion in microscopic Stage IB1 cervical cancer. Methods: A retrospective analysis was performed in 125 Stage IB1 cervical cancer patients who had no clinically visible lesions and were allotted based on microscopic findings after conization. All patients had magnetic resonance imaging (MRI) after conization and underwent type C2 radical hysterectomy. We suggested an MRI criterion for less radical surgery candidates as patients who had no demonstrable lesions on MRI. The rates of parametrial involvement (PMI) were estimated for patients that satisfied the inclusion criteria for ongoing studies and the MRI criterion. Results: The rate of pathologic PMI was 5.6% (7/125) in the study population. ConCerv and GOG-278 identified 11 (8.8%) and 14 (11.2%) patients, respectively, as less radical surgery candidates, and there were no false negative cases. SHAPE and MRI criteria identified 78 (62.4%) and 74 (59.2%) patients, respectively, as less radical surgery candidates; 67 patients were identified as less radical surgery candidates by both sets of criteria. Of these 67 patients, only one had pathologic PMI with tumor emboli. Conclusions: This study suggests that the criteria used in three ongoing studies and a new, simplified criterion using MRI can identify candidates for less radical surgery with acceptable false negativity in microscopic Stage IB1 disease.
引用
收藏
页数:7
相关论文
共 20 条
[1]  
[Anonymous], COCHRANE DATABASE SY
[2]   Small volume stage 1B1 cervical cancer Is radical surgery still necessary? [J].
Biliatis, Ioannis ;
Kucukmetin, Ali ;
Patel, Amit ;
Ratnavelu, Nithya ;
Cross, Paul ;
Chattopadhyay, Supratik ;
Galaal, Khadra ;
Naik, Raj .
GYNECOLOGIC ONCOLOGY, 2012, 126 (01) :73-77
[3]  
Covens A., GOG PROTOCOL 278
[4]   Parametrial Involvement in Radical Hysterectomy Specimens for Women With Early-Stage Cervical Cancer [J].
Frumovitz, Michael ;
Sun, Charlotte C. ;
Schmeler, Kathleen M. ;
Deavers, Michael T. ;
dos Reis, Ricardo ;
Levenback, Charles F. ;
Ramirez, Pedro T. .
OBSTETRICS AND GYNECOLOGY, 2009, 114 (01) :93-99
[5]   Can parametrectomy be avoided in early cervical cancer? An algorithm for the identification of patients at low risk for parametrial involvement [J].
Gemer, O. ;
Eitan, R. ;
Gdalevich, M. ;
Mamanov, A. ;
Piura, B. ;
Rabinovich, A. ;
Levavi, H. ;
Saar-Ryss, B. ;
Halperin, R. ;
Finci, S. ;
Beller, U. ;
Bruchim, I. ;
Levy, T. ;
Ben Shachar, I. ;
Ben Arie, A. ;
Lavie, O. .
EJSO, 2013, 39 (01) :76-80
[6]   Identification of a patient group at low risk for parametrial invasion in early-stage cervical cancer [J].
Jung, Dae-Chul ;
Kim, Mi-Kyung ;
Kang, Sokbom ;
Seo, Sang-Soo ;
Cho, Jeong Yeon ;
Park, Noh-Hyun ;
Song, Yong-Sang ;
Park, Sang-Yoon ;
Kang, Soon-Beom ;
Kim, Jae Weon .
GYNECOLOGIC ONCOLOGY, 2010, 119 (03) :426-430
[7]   Parametrial Involvement in FIGO Stage IB1 Cervical Carcinoma Diagnostic Impact of Tumor Diameter in Preoperative Magnetic Resonance Imaging [J].
Kamimori, Teruyo ;
Sakamoto, Kimihiko ;
Fujiwara, Kiyoshi ;
Umayahara, Kenji ;
Sugiyama, Yuko ;
Utsugi, Kuniko ;
Takeshima, Nobuhiro ;
Tanaka, Hiroko ;
Gomi, Naoya ;
Takizawa, Ken .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2011, 21 (02) :349-354
[8]  
Kasamatsu T., 1101 JCOG
[9]   Loop Electrosurgical Excision Procedure Findings for Identification of Patients With Early-Stage Cervical Cancer Suitable for Less Radical Surgery [J].
Kim, Mi-Kyung ;
Kim, Min A. ;
Kim, Jae Weon ;
Chung, Hyun Hoon ;
Park, Noh-Hyun ;
Song, Yong-Sang ;
Kang, Soon-Beom .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2012, 22 (07) :1214-1219
[10]   Stage IB1 Cervical Cancer: Role of Preoperative MR Imaging in Selection of Patients for Fertility-Sparing Radical Trachelectomy [J].
Lakhman, Yulia ;
Akin, Oguz ;
Park, Kay J. ;
Sarasohn, Debra M. ;
Zheng, Junting ;
Goldman, Debra A. ;
Sohn, Michael J. ;
Moskowitz, Chaya S. ;
Sonoda, Yukio ;
Hricak, Hedvig ;
Abu-Rustum, Nadeem R. .
RADIOLOGY, 2013, 269 (01) :149-158