P2X7 Receptor: A Potential Therapeutic Target for Depression?

被引：75
作者：
Deussing, Jan M. [1 ]
Arzt, Eduardo [2 ,3 ,4 ]
机构：
[1] Max Planck Inst Psychiat, Mol Neurogenet, Dept Stress Neurobiol & Neurogenet, Kraepelinstr 2-10, D-80804 Munich, Germany
[2] CONICET Partner Inst Max Planck Soc, Inst Invest Biomed Buenos Aires IBioBA, Buenos Aires, DF, Argentina
[3] Univ Buenos Aires, Buenos Aires, DF, Argentina
[4] Godoy Cruz 2390,C1425FQD, Buenos Aires, DF, Argentina
来源：
TRENDS IN MOLECULAR MEDICINE | 2018年 / 24卷 / 09期
关键词：
GATED ION-CHANNEL; P2X(7) RECEPTOR; BIPOLAR DISORDER; P2RX7; GENE; PORE FORMATION; KNOCKOUT MICE; EXPRESSION; STRESS; MOUSE; CELLS;
D O I：
10.1016/j.molmed.2018.07.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Depression is a prime contributor to global disease burden with 300 million affected patients worldwide. The persistent lack of progress with regards to pharmacotherapy stands in stark contrast to the pandemic magnitude of the disease. Alterations of inflammatory pathways in depressed patients, including altered circulating pro-inflammatory cytokines, have been put forward as a potential pathophysiological mechanism. The P2X7 receptor (P2X7R) plays an important role regulating the release of interleukin-1 beta and other cytokines. Comprehensive investigation of the P2X7R Gln460Arg missense mutation (rs2230912), which has been associated with major depression and bipolar disorder, has substantially contributed to validate P2X7R as a potential genetic risk factor. We propose that P2X7R is a putative target with good prospects for therapeutic intervention in depressive disorders.
引用
收藏
页码：736 / 747
页数：12
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