Phosphoinositide kinases

被引：556
作者：
Carpenter, CL
Cantley, LC
机构：
[1] BETH ISRAEL HOSP,DEPT MED,DIV SIGNAL TRANSDUCT,BOSTON,MA 02215
[2] HARVARD UNIV,SCH MED,DEPT CELL BIOL,BOSTON,MA 02115
来源：
CURRENT OPINION IN CELL BIOLOGY | 1996年 / 8卷 / 02期
关键词：
D O I：
10.1016/S0955-0674(96)80060-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recently, a number of cDNA clones with homology to the catalytic subunit of phosphoinositide g-kinase have been identified, and the sequence of the first cDNA clone encoding a phosphatidylinositol 4-phosphate 5-kinase has been published. Use of both dominant-negative mutants of phosphoinositide 3-kinase and the inhibitors wortmannin and LY294002 has identified a number of processes in which phosphoinositide 3-kinase participates, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis. Several possible biochemical targets of phosphoinositides have been found.
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页码：153 / 158
页数：6
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