Biphenotypic human papillomavirus-associated head and neck squamous cell carcinoma: a report of two cases

被引：2
作者：
Pitiyage, Gayani [1 ]
Lei, Mary [2 ]
Urbano, Teresa Guererro [2 ]
Odell, Edward [1 ,3 ]
Thavaraj, Selvam [1 ,3 ]
机构：
[1] Guys & St Thomas NHS Fdn Trust, Head & Neck Pathol, London SE1 9RT, England
[2] Guys & St Thomas NHS Fdn Trust, St Thomas Hosp, Dept Clin Oncol, London SE1 7EH, England
[3] Kings Coll London, Inst Dent, Mucosal & Salivary Biol, London SE1 9RT, England
来源：
DIAGNOSTIC PATHOLOGY | 2015年 / 10卷
关键词：
Biphasic; Biphenotypic; Differentiated; Human papillomavirus; Oropharyngeal; Squamous cell carcinoma; Undifferentiated; Variant; HPV; LYMPHOCYTES; OROPHARYNX; TONGUE; BASE;
D O I：
10.1186/s13000-015-0334-9
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Human papillomavirus-associated oropharyngeal squamous cell carcinoma is now recognised as a subtype of head and neck cancer with distinct clinical, molecular and histological characteristics. The majority of these carcinomas are of non-keratinising squamous type but there is a growing number of histomorphologic variants of this disease. Here we describe the clinical, histomorphologic and immunophenotypic features of two cases of human papillomavirus-associated oropharyngeal squamous cell carcinoma demonstrating a clearly delineated biphasic differentiated and undifferentiated phenotype.
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页数：6
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