Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations: Additional Results from the B-PROOF Study, an RCT

被引：44

作者：

de Koning, Elisa J. ^{[1
,2
]}

van der Zwaluw, Nikita L. ^{[3
]}

van Wijngaarden, Janneke P. ^{[3
]}

Sohl, Evelien ^{[1
,2
]}

Brouwer-Brolsma, Elske M. ^{[3
]}

van Marwijk, Harm W. J. ^{[1
,4
,5
]}

Enneman, Anke W. ^{[6
]}

Swart, Karin M. A. ^{[1
,2
]}

van Dijk, Suzanne C. ^{[6
]}

Ham, Annelies C. ^{[6
]}

van der Velde, Nathalie ^{[6
]}

Uitterlinden, Andre G. ^{[6
]}

Penninx, Brenda W. J. H. ^{[1
,7
]}

Elders, Petra J. M. ^{[4
]}

Lips, Paul ^{[1
,8
]}

Dhonukshe-Rutten, Rosalie A. M. ^{[3
]}

van Schoor, Natasja M. ^{[1
,2
]}

de Groot, Lisette C. P. G. M. ^{[3
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, POB 7057, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, POB 7057, NL-1007 MB Amsterdam, Netherlands

[3] Wageningen Univ, Div Human Nutr, POB 8129, NL-6700 EV Wageningen, Netherlands

[4] Vrije Univ Amsterdam, Med Ctr, Dept Gen Practice & Elderly Care Med, POB 7057, NL-1007 MB Amsterdam, Netherlands

[5] Univ Manchester, Inst Populat Hlth, Primary Care Res Ctr, Oxford Rd, Manchester M13 9PL, Lancs, England

[6] Erasmus Univ, Med Ctr, Dept Internal Med, POB 2040, NL-3000 CA Rotterdam, Netherlands

[7] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, GGZ InGeest, POB 7057, NL-1007 MB Amsterdam, Netherlands

[8] Vrije Univ Amsterdam, Med Ctr, Dept Internal Med Endocrinol, POB 7057, NL-1007 MB Amsterdam, Netherlands

来源：

NUTRIENTS | 2016年 / 8卷 / 11期

关键词：

homocysteine; hyperhomocysteinemia; depressive symptoms; quality of life; vitamin B-12; folic acid; older adults; randomized controlled trial; INDUCED NEUROTRANSMITTER DEFICIENCY; SELF-RATED HEALTH; PLASMA HOMOCYSTEINE; COGNITIVE FUNCTION; MOOD HYPOTHESIS; FOLATE; EQ-5D; WOMEN; RISK; QUESTIONNAIRE;

D O I：

10.3390/nu8110748

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Lowering elevated plasma homocysteine (Hcy) concentrations by supplementing vitamin B12 and folic acid may reduce depressive symptoms and improve health-related quality of life (HR-QoL) in older adults. This study aimed to test this hypothesis in a randomized controlled trial. Participants (N = 2919, >= 65 years, Hcy concentrations >= 12 mu mol/L) received either 500 mu g vitamin B12 and 400 mu g folic acid daily or placebo for two years. Both tablets contained 15 mu g vitamin D-3. Depressive symptoms were measured with the Geriatric Depression Scale-15 (GDS-15). HR-QoL was assessed with the SF-12 Mental and Physical component summary scores and the EQ-5D Index score and Visual Analogue Scale. Differences in two-year change scores were analyzed with Analysis of Covariance (ANCOVA). Hcy concentrations decreased more in the intervention group, but two-year change scores of the GDS-15 and three of four HR-QoL measures did not differ between groups. The EQ-5D Index score declined less in the intervention group than in the placebo group (mean change 0.00 vs. -0.02, p = 0.004). In conclusion, two-year supplementation with vitamin B-12 and folic acid in older adults with hyperhomocysteinemia showed that lowering Hcy concentrations does not reduce depressive symptoms, but it may have a small positive effect on HR-QoL.

引用

页数：16

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