Intravascular Large B-Cell Lymphoma

被引：61

作者：

Orwat, Dennis E. ^{[1
]}

Batalis, Nicholas I. ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA

来源：

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | 2012年 / 136卷 / 03期

关键词：

MALIGNANT ANGIOENDOTHELIOMATOSIS; CLINICAL PRESENTATION; HEMOPHAGOCYTOSIS; MANAGEMENT; DIAGNOSIS; NEOPLASM; VARIANT;

D O I：

10.5858/arpa.2010-0747-RS

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

A rare type of diffuse large B-cell lymphoma, intravascular large B-cell lymphoma primarily affects the middle-aged to elderly population, with a slight predominance in men. By the time of presentation, most patients have advanced, disseminated disease, and often the diagnosis is made at autopsy. Patients may present with any of a myriad of symptoms, with any tissue potentially being infiltrated. Central nervous system and cutaneous involvement is common, as is the presence of B symptoms including fever, weight loss, and night sweats. Morphologically, growth of neoplastic cells is restricted to the lumen of small vessels. The cells are large, with 1 or more prominent nucleoli, scant cytoplasm, and frequent mitotic figures, and are commonly positive for cluster of differentiation markers 79a, 20, and 19, as well as MUM1/IRF4 and Bcl-2. Intravascular large B-cell lymphoma is aggressive, and without treatment is rapidly fatal. (Arch Pathol Lab Med. 2012;136:333-338; doi:10.5858/arpa.2010-0747-RS)

引用

页码：333 / 338

页数：6

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