Total Synthesis of Tulearin C

被引：53
作者：
Lehr, Konrad [1 ]
Mariz, Ronaldo [1 ]
Leseurre, Lucie [1 ]
Gabor, Barbara [1 ]
Fuerstner, Alois [1 ]
机构：
[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 48期
关键词：
alkyne metathesis; alkynes; hydrosilylation; natural products; total synthesis; CLOSING ALKYNE METATHESIS; CONCISE TOTAL-SYNTHESIS; PROTECTING-GROUP-FREE; ENYNE-YNE METATHESIS; OLEFIN METATHESIS; 3-CARBOETHOXYPROPYLZINC IODIDE; STEREOSELECTIVE-SYNTHESIS; ORGANIC-SYNTHESIS; CROSS-METATHESIS; TERMINAL ALKYNES;
D O I：
10.1002/anie.201106117
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
With the help of the smaller brother: Although alkyne metathesis will always be the little brother of alkene metathesis, it allows problems to be solved that are currently beyond reach of the more famous sibling. This notion is exemplified by the tulearin macrolides, which could only be selectively forged by ring-closing alkyne metathesis (RCAM)/transreduction using the latest generation of alkyne metathesis catalysts. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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收藏
页码：11373 / 11377
页数：5
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