Epidural needle with embedded optical fibers for spectroscopic differentiation of tissue: ex vivo feasibility study

被引:30
作者
Desjardins, Adrien E. [1 ]
Hendriks, Benno H. W. [1 ]
van der Voort, Marjolein [1 ]
Nachabe, Rami [1 ]
Bierhoff, Walter [1 ]
Braun, Guus [1 ]
Babic, Drazenko [2 ]
Rathmell, James P. [3 ]
Holmin, Staffan [4 ,5 ]
Soderman, Michael [4 ,5 ]
Holmstrom, Bjorn [6 ,7 ]
机构
[1] Philips Res, Minimally Invas Healthcare Dept, Amsterdam, Netherlands
[2] Philips Healthcare, Best, Netherlands
[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Anesthesia Crit Care & Pain Med, Boston, MA USA
[4] Karolinska Univ Hosp, Dept Neuroradiol, Stockholm, Sweden
[5] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
[6] Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
[7] Karolinska Univ Hosp, Dept Anesthesiol & Intens Care, Huddinge, Sweden
关键词
COHERENCE TOMOGRAPHY; DIFFUSE-REFLECTANCE; SPECTRAL RANGE; IN-VIVO; SPACE; PROBE; HEMOGLOBIN; MYOGLOBIN;
D O I
10.1364/BOE.2.001452
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Epidural injection is commonly used to provide intraoperative anesthesia, postoperative and obstetric analgesia, and to treat acute radicular pain. Identification of the epidural space is typically carried out using the loss of resistance (LOR) technique, but the usefulness of this technique is limited by false LOR and the inability to reliably detect intravascular or subarachnoid needle placement. In this study, we present a novel epidural needle that allows for the acquisition of optical reflectance spectra from tissue close to the beveled surface. This needle has optical fibers embedded in the cannula that deliver and receive light. With two spectrometers, light received from tissue is resolved across the wavelength range of 500 to 1600 nm. To determine the feasibility of optical tissue differentiation, spectra were acquired from porcine tissues during a post mortem laminectomy. The spectra were processed with an algorithm that derives estimates of the hemoglobin and lipid concentrations. The results of this study suggest that the optical epidural needle has the potential to improve the accuracy of epidural space identification. (C)2010 Optical Society of America
引用
收藏
页码:1452 / 1461
页数:10
相关论文
共 34 条
[1]   Selective photothermolysis of lipid-rich tissues: A free electron laser study [J].
Anderson, R. Rox ;
Farinelli, William ;
Laubach, Hans ;
Manstein, Dieter ;
Yaroslavsky, Anna N. ;
Gubeli, Joseph, III ;
Jordan, Kevin ;
Neil, George R. ;
Shinn, Michelle ;
Chandler, Walter ;
Williams, Gwyn P. ;
Benson, Steven V. ;
Douglas, David R. ;
Dylla, H. F. .
LASERS IN SURGERY AND MEDICINE, 2006, 38 (10) :913-919
[2]   Spatially resolved reflectance spectroscopy for diagnosis of cervical precancer: Monte Carlo modeling and comparison to clinical measurements [J].
Arifler, Dizem ;
MacAulay, Calum ;
Follen, Michele ;
Richards-Kortum, Rebecca .
JOURNAL OF BIOMEDICAL OPTICS, 2006, 11 (06)
[3]   Optical properties effects upon the collection efficiency of optical fibers in different probe configurations [J].
Bargo, PR ;
Prahl, SA ;
Jacques, SL .
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 2003, 9 (02) :314-321
[4]   Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm [J].
Bashkatov, AN ;
Genina, EA ;
Kochubey, VI ;
Tuchin, VV .
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2005, 38 (15) :2543-2555
[5]   Effects of compression on soft tissue optical properties [J].
Chan, EK ;
Sorg, B ;
Protsenko, D ;
ONeil, M ;
Motamedi, M ;
Welch, AJ .
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 1996, 2 (04) :943-950
[6]   A REVIEW OF THE OPTICAL-PROPERTIES OF BIOLOGICAL TISSUES [J].
CHEONG, WF ;
PRAHL, SA ;
WELCH, AJ .
IEEE JOURNAL OF QUANTUM ELECTRONICS, 1990, 26 (12) :2166-2185
[7]   A NEW APPROACH FOR THE ESTIMATION OF BODY-COMPOSITION - INFRARED INTERACTANCE [J].
CONWAY, JM ;
NORRIS, KH ;
BODWELL, CE .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1984, 40 (06) :1123-1130
[8]   STUDY OF PHOTON MIGRATION DEPTHS WITH TIME-RESOLVED SPECTROSCOPY [J].
CUI, WJ ;
WANG, NG ;
CHANCE, B .
OPTICS LETTERS, 1991, 16 (21) :1632-1634
[9]   A DIFFUSION-THEORY MODEL OF SPATIALLY RESOLVED, STEADY-STATE DIFFUSE REFLECTANCE FOR THE NONINVASIVE DETERMINATION OF TISSUE OPTICAL-PROPERTIES INVIVO [J].
FARRELL, TJ ;
PATTERSON, MS ;
WILSON, B .
MEDICAL PHYSICS, 1992, 19 (04) :879-888
[10]   Identification of the epidural space using pressure measurement with the compuflo injection pump - A pilot study [J].
Ghelber, Oscar ;
Gebhard, Ralf E. ;
Vora, Sejal ;
Hagberg, Carin A. ;
Szmuk, Peter .
REGIONAL ANESTHESIA AND PAIN MEDICINE, 2008, 33 (04) :346-352