Tight junctions as regulators of tissue remodelling

被引：94

作者：

Balda, Maria S. ^{[1
]}

Matter, Karl ^{[1
]}

机构：

[1] UCL, UCL Inst Ophthalmol, Dept Cell Biol, London, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2016年 / 42卷

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

EPITHELIAL JUNCTIONS; BARRIER DYSFUNCTION; GENE-EXPRESSION; KNOCKOUT MICE; CELLS; CDC42; RHOA; ZO-1; DIFFERENTIATION; MORPHOGENESIS;

D O I：

10.1016/j.ceb.2016.05.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Formation of tissue barriers by epithelial and endothelial cells requires neighbouring cells to interact via intercellular junctions, which includes tight junctions. Tight junctions form a semipermeable paracellular diffusion barrier and act as signalling hubs that guide cell behaviour and differentiation. Components of tight junctions are also expressed in cell types not forming tight junctions, such as cardiomyocytes, where they associate with facia adherens and/or gap junctions. This review will focus on tight junction proteins and their importance in tissue homeostasis and remodelling with a particular emphasis on what we have learned from animal models and human diseases.

引用

页码：94 / 101

页数：8

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