Tight junctions as regulators of tissue remodelling

被引：94

作者：

Balda, Maria S. ^{[1
]}

Matter, Karl ^{[1
]}

机构：

[1] UCL, UCL Inst Ophthalmol, Dept Cell Biol, London, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2016年 / 42卷

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

EPITHELIAL JUNCTIONS; BARRIER DYSFUNCTION; GENE-EXPRESSION; KNOCKOUT MICE; CELLS; CDC42; RHOA; ZO-1; DIFFERENTIATION; MORPHOGENESIS;

D O I：

10.1016/j.ceb.2016.05.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Formation of tissue barriers by epithelial and endothelial cells requires neighbouring cells to interact via intercellular junctions, which includes tight junctions. Tight junctions form a semipermeable paracellular diffusion barrier and act as signalling hubs that guide cell behaviour and differentiation. Components of tight junctions are also expressed in cell types not forming tight junctions, such as cardiomyocytes, where they associate with facia adherens and/or gap junctions. This review will focus on tight junction proteins and their importance in tissue homeostasis and remodelling with a particular emphasis on what we have learned from animal models and human diseases.

引用

页码：94 / 101

页数：8

共 50 条

[1] Tight junctions and the regulation of gene expression
Balda, Maria S.
Matter, Karl
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2009, 1788 (04): : 761 - 767
[2] The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes
Chang, Ying-Ju
Pownall, Scott
Jensen, Thomas E.
Mouaaz, Samar
Foltz, Warren
Zhou, Lily
Liadis, Nicole
Woo, Minna
Hao, Zhenyue
Dutt, Previn
Bilan, Philip J.
Klip, Amira
Mak, Tak
Stambolic, Vuk
[J]. ELIFE, 2015, 4
[3] Junctional Adhesion Molecule-A Regulates Vascular Endothelial Growth Factor Receptor-2 Signaling-Dependent Mouse Corneal Wound Healing
Chatterjee, Sharmila
Wang, Yan
Duncan, Melinda K.
Naik, Ulhas P.
[J]. PLOS ONE, 2013, 8 (05):
[4] The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled
Choi, Wangsun
Jung, Kuo-Chen
Nelson, Kevin S.
Bhat, Manzoor A.
Beitel, Greg J.
Peifer, Mark
Fanning, Alan S.
[J]. MOLECULAR BIOLOGY OF THE CELL, 2011, 22 (12) : 2010 - 2030
[5] Inflammation and Disruption of the Mucosal Architecture in Claudin-7-Deficient Mice
Ding, Lei
Lu, Zhe
Foreman, Oded
Tatum, Rodney
Lu, Qun
Renegar, Randall
Cao, Jian
Chen, Yan-Hua
[J]. GASTROENTEROLOGY, 2012, 142 (02) : 305 - 315
[6] Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex
Elbediwy, Ahmed
Zihni, Ceniz
Terry, Stephen J.
Clark, Peter
Matter, Karl
Balda, Maria S.
[J]. JOURNAL OF CELL BIOLOGY, 2012, 198 (04) : 677 - 693
[7] Zonula occludens-1 and-2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia
Fanning, Alan S.
Van Itallie, Christina M.
Anderson, James M.
[J]. MOLECULAR BIOLOGY OF THE CELL, 2012, 23 (04) : 577 - 590
[8] Tight junctions and the regulation of gene expression
González-Mariscal, Lorenza
Dominguez-Calderon, Alaide
Raya-Sandino, Arturo
Mario Ortega-Olvera, Jose
Vargas-Sierra, Orlando
Martinez-Revollar, Gabriela
[J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2014, 36 : 213 - 223
[9] Paracingulin Regulates the Activity of Rac1 and RhoA GTPases by Recruiting Tiam1 and GEF-H1 to Epithelial Junctions
Guillemot, Laurent
Paschoud, Serge
Jond, Lionel
Foglia, Andrea
Citi, Sandra
[J]. MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (10) : 4442 - 4453
[10] MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly
Guillemot, Laurent
Guerrera, Diego
Spadaro, Domenica
Tapia, Rocio
Jond, Lionel
Citi, Sandra
[J]. MOLECULAR BIOLOGY OF THE CELL, 2014, 25 (13) : 1995 - 2005

← 1 2 3 4 5 →