Efficient Synthesis of Tetrahydropyrimidines and Pyrrolidines by a Multicomponent Reaction of Dialkyl Acetylenedicarboxylates (=Dialkyl But-2-ynedioates), Amines, and Formaldehyde in the Presence of Iodine as a Catalyst

被引：9

作者：

Das, Biswanath ^{[1
]}

Kanth, Boddu Shashi ^{[1
]}

Shinde, Digambar Balaji ^{[1
]}

Kamble, Vinod T. ^{[2
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500607, Andhra Pradesh, India

[2] Marathwada Univ, Organ Chem Res Lab, Sch Chem Sci, Nanded 431606, Maharashtra, India

来源：

HELVETICA CHIMICA ACTA | 2011年 / 94卷 / 11期

关键词：

Pyrimidines; tetrahydro-; Pyrrolidines; Multicomponent reactions; Iodine; Catalysis; PHOSPHONATES;

D O I：

10.1002/hlca.201100185

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Iodine was explored as an efficient catalyst for the synthesis of tetrahydropyrimidines 4 and pyrrolidines 5 by a multicomponent reaction of dialkyl acetylenedicarboxylates (=dialkyl but-2-ynedioates) 1, amines 2, and HCHO 3 at room temperature (Scheme). When the molar ratios of these substrates were 1:2:4 and 1:1:4, tetrahydropyrimidines and pyrrolidines were formed, respectively. The products were obtained in high yields (7385%) within a short period of time (2535 min).

引用

页码：2087 / 2091

页数：5

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