Zwitterionic polymer functionalization of polysulfone membrane with improved antifouling property and blood compatibility by combination of ATRP and click chemistry

被引：89

作者：

Xiang, Tao ^{[1
]}

Lu, Ting ^{[1
]}

Xie, Yi ^{[1
]}

Zhao, Wei-Feng ^{[1
,2
]}

Sun, Shu-Dong ^{[1
]}

Zhao, Chang-Sheng ^{[1
]}

机构：

[1] Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China

[2] KTH Royal Inst Technol, Sch Chem Sci & Engn, Fiber & Polymer Technol, Tekn Ringen 56-58, SE-10044 Stockholm, Sweden

来源：

ACTA BIOMATERIALIA | 2016年 / 40卷

基金：

中国国家自然科学基金;

关键词：

Zwitterionic polymer; Antifouling; Blood compatibility; ATRP; Click chemistry; TRANSFER RADICAL POLYMERIZATION; SURFACE-INITIATED ATRP; PARTIAL THROMBOPLASTIN TIME; REVERSE-OSMOSIS MEMBRANES; LAYER-BY-LAYER; POLYETHERSULFONE MEMBRANE; BLOCK-COPOLYMERS; ULTRAFILTRATION MEMBRANES; PLATELET-ADHESION; CITRIC-ACID;

D O I：

10.1016/j.actbio.2016.03.044

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The chemical compositions are very important for designing blood-contacting membranes with good antifouling property and blood compatibility. In this study, we propose a method combining ATRP and click chemistry to introduce zwitterionic polymer of poly(sulfobetaine methacrylate) (PSBMA), negatively charged polymers of poly(sodium methacrylate) (PNaMAA) and/or poly(sodium p-styrene sulfonate) (PNaSS), to improve the antifouling property and blood compatibility of polysulfone (PSf) membranes. Attenuated total reflectance-Fourier transform infrared spectra, X-ray photoelectron spectroscopy and water contact angle results confirmed the successful grafting of the functional polymers. The antifouling property and blood compatibility of the modified membranes were systematically investigated. The zwitterionic polymer (PSBMA) grafted membranes showed good resistance to protein adsorption and bacterial adhesion; the negatively charged polymer (PNaSS or PNaMAA) grafted membranes showed improved blood compatibility, especially the anticoagulant property. Moreover, the PSBMA/PNaMAA modified membrane showed both antifouling property and anticoagulant property, and exhibited a synergistic effect in inhibiting blood coagulation. The functionalization of membrane surfaces by a combination of ATRP and click chemistry is demonstrated as an effective route to improve the antifouling property and blood compatibility of membranes in blood-contact. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：162 / 171

页数：10

共 54 条

[21] Polymers at interfaces: Using atom transfer radical polymerization in the controlled growth of homopolymers and block copolymers from silicon surfaces in the absence of untethered sacrificial initiator [J].