Rise of the Clones: Myelodysplastic Syndrome to Secondary Acute Myeloid Leukemia

被引：2
|
作者：
Romine, Kyle A. [1 ]
van Galen, Peter [2 ]
机构：
[1] Oregon Hlth & Sci Univ, Dept Cell Dev & Canc Biol, Portland, OR 97201 USA
[2] Brigham & Womens Hosp, Div Hematol, 75 Francis St, Boston, MA 02115 USA
来源：
BLOOD CANCER DISCOVERY | 2022年 / 3卷 / 04期
关键词：
D O I：
10.1158/2643-3230.BCD-22-0046
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Myelodysplastic syndrome (MDS) describes a family of blood disorders driven by the clonal expansion of mutated blood cells that can evolve into secondary acute myeloid leukemia (sAML). Two new studies use single-cell and deep sequencing to elucidate the progression of MDS to AML, revealing discrete clonal architectures and the driving role of signaling mutations.
引用
收藏
页码：270 / 272
页数：3
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