Effects of acute metabolic stress on the dopaminergic and pituitary-adrenal axis activity in patients with schizophrenia, their unaffected siblings and controls

被引：61

作者：

Brunelin, Jerome ^{[1
,2
,3
,4
,5
]}

d'Amato, Thierry ^{[1
,2
,3
,4
]}

van Os, Jim ^{[5
,6
]}

Cochet, Alain ^{[1
,2
,3
,4
]}

Suaud-Chagny, Marie-Frangoise ^{[1
,2
,3
,4
]}

Saoud, Mohamed ^{[1
,2
,4
]}

机构：

[1] CH Le Vinatier, Serv Pr Amato, F-69677 Bron, France

[2] Univ Lyon, F-69003 Lyon, France

[3] Univ Lyon 1, F-69365 Lyon, France

[4] Hop Neurol, IFNL, F-69394 Lyon, France

[5] Maastricht Univ, EURON, S Limburg Mental Hlth Res & Teaching Network, Dept Psychiat & Neuropsychol, NL-6200 MD Maastricht, Netherlands

[6] Inst Psychiat, Div Psychol Med, London SE5 8AF, England

来源：

SCHIZOPHRENIA RESEARCH | 2008年 / 100卷 / 1-3期

关键词：

schizophrenia; vulnerability; 2DG; stress;

D O I：

10.1016/j.schres.2007.11.009

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

A genetically mediated abnormal sensitivity to stress is thought to play a role in the onset, exacerbation and relapse of schizophrenia. In a double blind, placebo-controlled crossover study, peak increases in plasma ACTH (Delta ACTH) and homovanillic-acid, a dopamine metabolite, (Delta HVA) following exposure to a metabolic stressor(2DG) were studied in unaffected siblings of patients with schizophrenia (n = 15), their patient relatives (n = 15) and healthy controls (n = 14). Siblings showed a stress response (both Delta ACTH and Delta HVA) that was significantly greater compared to controls and significantly less pronounced compared to patients. The results suggest that the genetic risk for schizophrenia may be characterized by an enhanced sensitivity to stress. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：206 / 211

页数：6

共 28 条

[1] Effects of acute metabolic stress on striatal dopamine release in healthy volunteers [J].