TUMOR-INDUCED OSTEOMALACIA ORIGINATING FROM THE TEMPORAL BONE: A CASE REPORT

被引:12
作者
Kobayashi, Kenya [1 ,2 ]
Nakao, Kazunari [1 ]
Kawai, Kensuke [3 ]
Ito, Ken [4 ]
Hukumoto, Seiji [5 ]
Asakage, Takahiro [2 ]
Oota, Satoshi [6 ]
Motoi, Ryo [7 ]
机构
[1] NTT EC, Kanto Med Ctr, Dept Otolaryngol Head & Neck Surg, Tokyo, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Tokyo, Japan
[3] Univ Tokyo, Grad Sch Med, Dept Neurosurg, Tokyo, Japan
[4] Teikyo Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Tokyo 173, Japan
[5] Univ Tokyo, Grad Sch Med, Dept Endocrinol, Tokyo, Japan
[6] Univ Tokyo, Grad Sch Med, Dept Pathol, Tokyo, Japan
[7] Teikyo Univ, Sch Med, Dept Pathol, Tokyo 173, Japan
来源
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2011年 / 33卷 / 07期
关键词
TIO; temporal bone; skull base surgery; FGF-23; embolization of tumor; PHOSPHATURIC MESENCHYMAL TUMOR; ONCOGENIC OSTEOMALACIA; RICKETS;
D O I
10.1002/hed.21355
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background. Tumor-induced osteomalacia (TIO) is a rare clinical entity in which secondary osteomalacia is induced by tumor-related products. Fibroblast growth factor 23 (FGF-23) mRNA is overexpressed in the tumor tissue, leading to impaired reabsorption of phosphorus in the renal tubules and hypophosphatemia. Curative treatment is considered to be total resection of the tumor. Methods and Results. A 53-year-old woman had experienced systemic bone pain and muscle weakness for several years. She had refractory hypophosphatemia and marked elevation of serum FGF-23 level. Whole body imaging eventually revealed a hypervascular mass in the right temporal bone, leading to a diagnosis of TIO. She underwent skull-base surgery after embolization of the tumor. After the en bloc resection, FGF-23 became undetectable, phosphate reabsorption normalized, and all symptoms resolved. Conclusions. We discuss the clinical features and treatment options for this rare disease. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 1072-1075, 2011
引用
收藏
页码:1072 / 1075
页数:4
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