Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury

被引:27
作者
Favre, Guillaume [1 ]
Mazzetti, Sara [2 ]
Gengler, Carole [3 ]
Bertelli, Claire [4 ]
Schneider, Juliane [5 ]
Laubscher, Bernard [2 ,6 ]
Capoccia, Romina [7 ]
Pakniyat, Fatemeh [7 ]
Ben Jazia, Ines [7 ]
Eggel-Hort, Beatrice [8 ]
de Leval, Laurence [3 ]
Pomar, Leo [1 ,9 ]
Greub, Gilbert [4 ,10 ]
Baud, David [1 ]
Giannoni, Eric [5 ]
机构
[1] Univ Lausanne, Dept Woman Mother Child, Maternofetal & Obstet Res Unit, Lausanne Univ Hosp, CH-1011 Lausanne, Switzerland
[2] Univ Lausanne, Dept Mother Woman Child, Clin Pediat, Lausanne Univ Hosp, CH-1011 Lausanne, Switzerland
[3] Univ Lausanne, Inst Pathol, Dept Lab Med & Pathol, Lausanne Univ Hosp, CH-1011 Lausanne, Switzerland
[4] Univ Lausanne, Inst Microbiol, Lausanne Univ Hosp, CH-1011 Lausanne, Switzerland
[5] Univ Lausanne, Dept Mother Woman Child, Clin Neonatol, Lausanne Univ Hosp, CH-1011 Lausanne, Switzerland
[6] Reseau Hosp Neuchatelois, Dept Pediat, CH-2000 Neuchatel, Switzerland
[7] Reseau Hosp Neuchatelois, Dept Obstet & Gynecol, CH-2000 Neuchatel, Switzerland
[8] Ctr Hosp Valais Romand, Hop Valais, Dept Obstet & Gynecol, Site Sion, CH-1951 Sion, Switzerland
[9] Univ Appl Sci & Arts Western Switzerland, Sch Hlth Sci HESAV, Midwifery Dept, CH-1011 Lausanne, Switzerland
[10] Univ Lausanne, Dept Internal Med, Infect Dis Serv, Lausanne Univ Hosp, CH-1011 Lausanne, Switzerland
来源
VIRUSES-BASEL | 2021年 / 13卷 / 12期
关键词
SARS-CoV-2; COVID-19; perinatal; placental; brain injury; fetal movements; neurosonography; MRI;
D O I
10.3390/v13122517
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 and 32 + 1 weeks of gestation, and leading to brain injury. Placental examination revealed extensive and multifocal chronic intervillositis, with intense cytoplasmic positivity for SARS-CoV-2 spike antibody and SARS-CoV-2 detection by RT-qPCR. Vertical transmission was confirmed in one case, and both neonates developed extensive cystic peri-ventricular leukomalacia.
引用
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页数:11
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