TRIM21/Ro52-Roles in Innate Immunity and Autoimmune Disease

被引：68
作者：
Jones, Esther L. [1 ]
Laidlaw, Stephen M. [1 ]
Dustin, Lynn B. [1 ]
机构：
[1] Univ Oxford, Kennedy Inst Rheumatol, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
关键词：
innate immunity; E3 ubiquitin ligase; autoimmune disease; Sjogren's syndrome; Fc receptor; systemic lupus erythematosus; intracellular antibodies; SYSTEMIC-LUPUS-ERYTHEMATOSUS; DEPENDENT CYTOKINE EXPRESSION; SYNDROME-LIKE DISORDER; SJOGRENS-SYNDROME; AUTOANTIGEN RO52; NONNEUTRALIZING ANTIBODIES; COILED-COIL; SS-A/RO; MONOCLONAL-ANTIBODIES; ANTI-RO52; ANTIBODY;
D O I：
10.3389/fimmu.2021.738473
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjogren's syndrome, systemic lupus erythematosus, and other rheumatic autoimmune diseases. Here, we summarise the structure and function of this enzyme, its roles in innate immunity, adaptive immunity and cellular homeostasis, the pathogenesis of autoimmunity against TRIM21, and the potential impacts of autoantibodies to this intracellular protein.
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页数：18
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