Modulation of membrane-cytoskeleton interactions: ezrin as key player

被引：15
|
作者：
Yin, Lei-Miao [1 ]
Schnoor, Michael [2 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Yueyang Hosp, Shanghai, Peoples R China
[2] Natl Polytech Inst Cinvestav IPN, Ctr Invest & Adv Studies, Dept Mol Biomed, Mexico City 07360, DF, Mexico
来源：
TRENDS IN CELL BIOLOGY | 2022年 / 32卷 / 02期
基金：
中国国家自然科学基金;
关键词：
METASTASIS;
D O I：
10.1016/j.tcb.2021.09.005
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Membrane-cytoskelet on interactions (MCIs) are mediated by actinbinding proteins (ABPs). Ezrin is a crucial ABP that links membranes to actin filaments during lamellipodia formation, cell polarization, and migration. We discuss the concept of MCI and the potential of ezrin as a druggable target for treating inflammatory diseases and cancers.
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页码：94 / 97
页数：4
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