Ser/Thr phosphorylation as a regulatory mechanism in bacteria

被引：101

作者：

Dworkin, Jonathan ^{[1
]}

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Microbiol & Immunol, New York, NY 10032 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2015年 / 24卷

关键词：

PROTEIN-KINASE; STAPHYLOCOCCUS-AUREUS; CELL-DIVISION; MYCOBACTERIUM-TUBERCULOSIS; STREPTOCOCCUS-PNEUMONIAE; PHOSPHOPROTEOME ANALYSIS; INTERACTION NETWORK; DNA-BINDING; SERINE/THREONINE; REVEALS;

D O I：

10.1016/j.mib.2015.01.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This review will discuss some recent work describing the role of Ser/Thr phosphorylation as a post-translational mechanism of regulation in bacteria. I will discuss the interaction between bacterial eukaryotic-like Serahr kinases (eSTKs) and two-component systems as well as hints as to physiological function of eSTKs and their cognate eukaryotic-like phosphatases (eSTPs). In particular, I will highlight the role of eSTKs and eSTPs in the regulation of peptidoglycan metabolism and protein synthesis. In addition, I will discuss how data from phosphoproteomic surveys suggest that Ser/Thr phosphorylation plays a much more significant physiological role than would be predicted simply based on in vivo and in vitro analyses of individual kinases.

引用

页码：47 / 52

页数：6

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