A 3D Printed Implantable Device for Voiding the Bladder Using Shape Memory Alloy (SMA) Actuators

被引：45

作者：

Hassani, Faezeh Arab ^{[1
,2
,3
,4
]}

Peh, Wendy Yen Xian ^{[2
]}

Gammad, Gil Gerald Lasam ^{[2
]}

Mogan, Roshini Priya ^{[2
]}

Ng, Tze Kiat ^{[5
]}

Kuo, Tricia Li Chuen ^{[6
]}

Ng, Lay Guat ^{[6
]}

Luu, Percy ^{[2
]}

Yen, Shih-Cheng ^{[1
,2
,3
]}

Lee, Chengkuo ^{[1
,2
,3
,4
]}

机构：

[1] Natl Univ Singapore, Fac Engn, Dept Elect & Comp Engn, 4 Engn Dr 3,05-45, Singapore 117583, Singapore

[2] Natl Univ Singapore, Singapore Inst Neurotechnol, 28 Med Dr,05 COR, Singapore 117456, Singapore

[3] Natl Univ Singapore, Ctr Intelligent Sensors, 4 Engn Dr 3, Singapore 117576, Singapore

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Biomed Inst Global Hlth Res & Technol BIGHEART, 14 Med Dr 14-01, Singapore 117599, Singapore

[5] Raffles Hosp, 585 North Bridge Rd, Singapore 188770, Singapore

[6] Singapore Gen Hosp, Outram Rd, Singapore 169608, Singapore

来源：

ADVANCED SCIENCE | 2017年 / 4卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

3D printing; actuators; flexible electronics; shape memory alloy; under active bladder; ELECTRICAL-STIMULATION; UNDERACTIVE BLADDER; DYSFUNCTION; MODEL;

D O I：

10.1002/advs.201700143

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Underactive bladder or detrusor underactivity (DU) is defined as a reduction of contraction strength or duration of the bladder wall. Despite the serious healthcare implications of DU, there are limited solutions for affected individuals. A flexible 3D printed implantable device driven by shape memory alloys (SMA) actuators is presented here for the first time to physically contract the bladder to restore voluntary control of the bladder for individuals suffering from DU. This approach is used initially in benchtop experiments with a rubber balloon acting as a model for the rat bladder to verify its potential for voiding, and that the operating temperatures are safe for the eventual implantation of the device in a rat. The device is then implanted and tested on an anesthetized rat, and a voiding volume of more than 8% is successfully achieved for the SMA-based device without any surgical intervention or drug injection to relax the external sphincter.

引用

页数：10

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