Synthesis, characterization, DNA interaction and in vitro cytotoxicity activities of ruthenium(II) Schiff base complexes

被引：34

作者：

Sathiyaraj, Subbaiyan ^{[1
]}

Butcher, Ray J. ^{[2
]}

Jayabalakrishnan, Chinnasamy ^{[1
]}

机构：

[1] Sri Ramakrishna Mission Vidyalaya Coll Arts & Sci, Postgrad & Res Dept Chem, Coimbatore 641020, Tamil Nadu, India

[2] Howard Univ, Dept Chem, Washington, DC 20059 USA

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2012年 / 1030卷

关键词：

Ruthenium(II) complexes; Aminobenzothiazole; Crystal structure; DNA-interaction; Cytotoxicity; BINDING PROPERTIES; METAL-COMPLEXES; ANTITUMOR; LIGANDS; CLEAVAGE;

D O I：

10.1016/j.molstruc.2012.07.021

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

DNA binding, cleavage and cytotoxicity characteristics of a novel Schiff base ligand 3-(benzothiazol-2-yliminomethyl)-naphthalen-2-ol and ruthenium(II) complexes have been investigated. The DNA interaction properties of the complexes have been investigated using absorption spectra, as well as gel electrophoresis studies. Intrinsic binding constant (K-b) has been estimated under similar set of experimental conditions. Absorption spectral study indicate that the ligand and ruthenium(II) complexes has intrinsic binding constant in the range of 1.4-7.2 X 10(4) M-1. Ruthenium(II)complexes show more binding ability than the ligand. Further, in vitro cytotoxicity study of the ligand and the complexes exhibited antitumor activity against HeLa and HEp2 tumor cells. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：95 / 103

页数：9

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