Hexosamine pathway activation and O-linked-N-acetylglucosamine - Novel mediators of endothelial dysfunction in hyperglycemia and diabetes

被引：6

作者：

Beyer, Andreas M. ^{[1
,2
]}

Weihrauch, Dorothee ^{[2
,3
]}

机构：

[1] Med Coll Wisconsin, Dept Med, Div Cardiol, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Ctr Cardiovasc, Milwaukee, WI 53226 USA

[3] Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA

来源：

VASCULAR PHARMACOLOGY | 2012年 / 56卷 / 3-4期

关键词：

NITRIC-OXIDE SYNTHASE; POSTTRANSLATIONAL MODIFICATION; ENOS FUNCTION; PHOSPHORYLATION; SUPEROXIDE; PROTEINS; STRESS; CELLS;

D O I：

10.1016/j.vph.2012.01.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：113 / 114

页数：2

共 23 条

[1] Biochemistry and molecular cell biology of diabetic complications [J].

Brownlee, M .

NATURE, 2001, 414 (6865) :813-820

[2] Superoxide Induces Endothelial Nitric-oxide Synthase Protein Thiyl Radical Formation, a Novel Mechanism Regulating eNOS Function and Coupling [J].

Chen, Chun-An ;

Lin, Cho-Hao ;

Druhan, Lawrence J. ;

Wang, Tse-Yao ;

Chen, Yeong-Renn ;

Zweier, Jay L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (33) :29098-29107

[3] S-glutathionylation uncouples eNOS and regulates its cellular and vascular function [J].

Chen, Chun-An ;

Wang, Tse-Yao ;

Varadharaj, Saradhadevi ;

Reyes, Levy A. ;

Hemann, Craig ;

Talukder, M. A. Hassan ;

Chen, Yeong-Renn ;

Druhan, Lawrence J. ;

Zweier, Jay L. .

NATURE, 2010, 468 (7327) :1115-U521

[4]

De Young L, 2004, J ANDROL, V25, P830

[5] Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation [J].

Dimmeler, S ;

Fleming, I ;

Fisslthaler, B ;

Hermann, C ;

Busse, R ;

Zeiher, AM .

NATURE, 1999, 399 (6736) :601-605

[6] Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site [J].

Du, XL ;

Edelstein, D ;

Dimmeler, S ;

Ju, QD ;

Sui, C ;

Brownlee, M .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (09) :1341-1348

[7] Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells [J].

Federici, M ;

Menghini, R ;

Mauriello, A ;

Hribal, ML ;

Ferrelli, F ;

Lauro, D ;

Sbraccia, P ;

Spagnoli, LG ;

Sesti, G ;

Lauro, R .

CIRCULATION, 2002, 106 (04) :466-472

[8] Phosphorylation of Thr495 regulates Ca2+/calmodulin-dependent endothelial nitric oxide synthase activity [J].

Fleming, I ;

Fisslthaler, B ;

Dimmeler, S ;

Kemp, BE ;

Busse, R .

CIRCULATION RESEARCH, 2001, 88 (11) :E68-E75

[9] Molecular mechanisms underlying the activation of eNOS [J].

Fleming, Ingrid .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2010, 459 (06) :793-806

[10] Basal endothelial nitric oxide synthase (eNOS) phosphorylation on Ser1177 occurs in a stable microtubule- and tubulin acetylation-dependent manner [J].

Giustiniani, J. ;

Couloubaly, S. ;

Baillet, A. ;

Pourci, M-L. ;

Cantaloube, I. ;

Fourniat, C. ;

Paul, J-L. ;

Poues, C. .

EXPERIMENTAL CELL RESEARCH, 2009, 315 (20) :3509-3520

← 1 2 3 →