Diagnostic applications of Raman spectroscopy

被引：172
作者：
Tu, Qiang [2 ]
Chang, Chang [1 ,2 ]
机构：
[1] Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA
[2] Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA 19104 USA
来源：
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2012年 / 8卷 / 05期
关键词：
Raman spectroscopy; SERS; Cancer diagnosis; Transplant rejection; WALLED CARBON NANOTUBES; IN-VIVO; BREAST-CANCER; ALLOGRAFT-REJECTION; SILVER NANOPARTICLES; DELIVERY-SYSTEMS; DRUG-DELIVERY; T-LYMPHOCYTES; LIVING MICE; SERS;
D O I：
10.1016/j.nano.2011.09.013
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Raman spectroscopy has been widely used in various fields of science. It has been successfully utilized to qualitatively and quantitatively determine the molecular compositions of solid, liquid, and gaseous samples. This review focuses on the diagnostic applications of Raman spectroscopy in the past 5 years, with specific emphasis on transplant allograft rejection and cancer detections. First we introduce the principle of Raman spectroscopy and associated surface enhancement techniques. Various recent biomedical and clinical applications of Raman spectroscopy are then reviewed in detail. Finally, we present the experimental and analytical techniques required to implement Raman spectroscopy in a laboratory.
引用
收藏
页码：545 / 558
页数：14
相关论文
共 123 条
[1]  
Adams MJ, 2004, CHEMOMETRICS ANAL SP
[2]   In Situ Plasmon-Heating-induced Generation of Au/TiO2 "Hot Spots" on Colloidal Crystals [J].
Alessandri, Ivano ;
Ferroni, Matteo ;
Depero, Laura E. .
CHEMPHYSCHEM, 2009, 10 (07) :1017-1022
[3]  
[Anonymous], 2010, Cancer facts and figures
[4]  
[Anonymous], 2001, Handbook of Raman spectroscopy: from the research laboratory to the process line
[5]   Synthesis of Magnetic Fe2O3/Au Core/Shell Nanoparticles for Bioseparation and Immunoassay Based on Surface-Enhanced Raman Spectroscopy [J].
Bao, Fang ;
Yao, Jian-Lin ;
Gu, Ren-Ao .
LANGMUIR, 2009, 25 (18) :10782-10787
[6]   Identification of Raman spectroscopic markers for the characterization of normal and adenocarcinomatous colonic tissues [J].
Beljebbar, A. ;
Bouche, O. ;
Diebold, M. D. ;
Guillou, P. J. ;
Palot, J. P. ;
Eudes, D. ;
Manfait, M. .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2009, 72 (03) :255-264
[7]  
Bergholt MS, 2011, J BIOMED OPT, P16
[8]   Targeted Killing of Cancer Cells in Vivo and in Vitro with EGF-Directed Carbon Nanotube-Based Drug Delivery [J].
Bhirde, Ashwin A. ;
Patel, Vyomesh ;
Gavard, Julie ;
Zhang, Guofeng ;
Sousa, Alioscka A. ;
Masedunskas, Andrius ;
Leapman, Richard D. ;
Weigert, Roberto ;
Gutkind, J. Silvio ;
Rusling, James F. .
ACS NANO, 2009, 3 (02) :307-316
[9]  
Biris AS, 2009, J BIOMED OPT, P14
[10]   Imaging live cells grown on a three dimensional collagen matrix using Raman microspectroscopy [J].
Bonnier, F. ;
Knief, P. ;
Lim, B. ;
Meade, A. D. ;
Dorney, J. ;
Bhattacharya, K. ;
Lyng, F. M. ;
Byrne, H. J. .
ANALYST, 2010, 135 (12) :3169-3177
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