Methoxybutropate microencapsulation by gelatin-acacia complex coacervation

被引:24
作者
Palmieri, GF
Lauri, D
Martelli, S
Wehrle, P
机构
[1] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, Italy
[2] Fac Pharm Strasbourg, Lab Pharmacotech, F-67401 Illkirch Graffenstaden, France
关键词
coacervation; freeze-drying; methoxybutropate; microcapsules; spray-drying;
D O I
10.1081/DDC-100102189
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Microcapsules of methoxybutropate solid particles or of an oily saturated solution of the same drug were prepared by complex coacervation between gelatin and acacia and dried with three different methods: isopropanol addition, spray-drying, and freeze-drying. Successively, microparticles were analyzed by infrared thermobalance, ultraviolet (UV) spectroscopy, optical and scanning electron microscopy, and sieves to find out parameters such as yield, moisture content, encapsulation percentage, morphology of solid particles, and particle size. Results highlighted that the most appropriate drying method for industrial purposes was spray-drying, particularly for oil-containing microcapsule formulations.
引用
收藏
页码:399 / 407
页数:9
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