Exercise and newer insulins:: How much glucose supplement to avoid hypoglycemia?

被引:27
作者
Dubé, MC
Weisnagel, SJ
Prud'Homme, D
Lavoie, C
机构
[1] Univ Quebec Trois Rivieres, Phys Act Sci Dept, Trois Rivieres, PQ G9A 5H7, Canada
[2] Univ Laval, Fac Med, Dept Physiol & Endocrinol, Quebec City, PQ, Canada
[3] Univ Laval, Dept Prevent & Social Med, Div Kinesiol, Quebec City, PQ, Canada
[4] Univ Laval, Diabet Res Unit, CRML, CRCHUL, Quebec City, PQ, Canada
[5] Univ Ottawa, Fac Hlth Sci, Sch Human Kinet, Ottawa, ON, Canada
关键词
safe blood glucose; intensive insulin therapy; exercise; Type; 1; diabetes; hypoglycemia;
D O I
10.1249/01.mss.0000174950.25188.36
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
Purpose: To determine the glucose supplement required to prevent hypoglycemia during moderate-intensity exercise in Type I diabetic patients using newer analog insulins. Methods: Nine subjects performed 60 min of ergocycle exercise (50% VO2max), 3 h after a standard breakfast in three different conditions. Subjects were randomly assigned to preexercise liquid glucose supplement of 0 g of glucose (OG), 15 g of glucose (15G), and 30 g of glucose (30G). Blood glucose (BG) was measured before, during, and following the exercise. All subjects used Humulin No (N) and analog insulin Humalog (R) (Lispro). A dextrose infusion was initiated when BG fell below 5 mmol(.)L(-1). Results: There was no significant difference in the magnitude of the decrease in BG exercise-induced when comparing the three experimental conditions. However, the quantity of dextrose infused was significantly higher in the OG (10.5 +/- 3.2 g) than in the 15G (3.5 +/- 1.8 g) or the 30G conditions (1.6 +/- 1.0 g). The addition of a glucose supplement (15G or 30G) significantly prolonged the delay before the need for dextrose infusion (31.7 +/- 7.5, 51.3 +/- 4.2, and 55.6 +/- 2.6 min; OG, 15G, and 30G, respectively). The quantity of dextrose infusion was plotted against the three preexercise glucose supplements and a regression equation obtained. Solving this equation, a glucose supplement of 40 g was estimated in order to maintain BG levels within the normal range during and after exercise. Conclusion: For 60 min of late postprandial exercise followed by 60 min of recovery, an estimated 40 g of a liquid glucose supplement, ingested 15 min prior exercise, would seem likely to help maintain safe BG levels in subjects using N-Lispro.
引用
收藏
页码:1276 / 1282
页数:7
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