MicroRNAs in inflammation and immune responses

被引：175

作者：

Contreras, J. ^{[1
,2
]}

Rao, D. S. ^{[1
,3
,4
,5
]}

机构：

[1] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Cellular & Mol Pathol PhD Program, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Broad Stem Cell Res Ctr, Los Angeles, CA 90095 USA

[5] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

LEUKEMIA | 2012年 / 26卷 / 03期

关键词：

microRNA; inflammation; NF-kappa B; NF-KAPPA-B; HEMATOPOIETIC STEM-CELLS; INDUCED CYTIDINE DEAMINASE; GERMINAL CENTER RESPONSE; TOLL-LIKE RECEPTORS; REGULATORY T-CELLS; TRANSCRIPTION FACTORS; GENE-REGULATION; SMALL RNAS; IN-VIVO;

D O I：

10.1038/leu.2011.356

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are important regulators of gene expression in the immune system. In a few short years, their mechanism of action has been described in various cell lineages within the immune system, targets have been defined and their unique contributions to immune cell function have been examined. Certain miRNAs serve in important negative feedback loops in the immune system, whereas others serve to amplify the response of the immune system by repressing inhibitors of the response. Here, we review some of the better understood mechanisms as well as some emerging concepts of miRNA function. Future work will likely involve defining the function of specific miRNAs in specific immune cell lineages and to utilize them in the design of therapeutic strategies for diseases involving the immune system. Leukemia (2012) 26, 404-413; doi:10.1038/leu.2011.356; published online 20 December 2011

引用

页码：404 / 413

页数：10

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