A universal strategy for preparing protected C-terminal peptides on the solid phase through an intramolecular click chemistry-based handle

被引：10

作者：

Gongora-Benitez, Miriam ^{[2
]}

Cristau, Michele ^{[1
]}

Giraud, Matthieu ^{[1
]}

Tulla-Puche, Judit ^{[2
,3
]}

Albericio, Fernando ^{[2
,3
,4
]}

机构：

[1] Lonza Ltd, CH-3930 Visp, Switzerland

[2] Inst Res Biomed, Barcelona 08028, Spain

[3] PCB, Networking Ctr Bioengn Biomat & Nanomed, CIBER BBN, Barcelona 08028, Spain

[4] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 17期

关键词：

DIKETOPIPERAZINE FORMATION;

D O I：

10.1039/c2cc17222d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new universal strategy exploits DKP formation in a dipeptide moiety whose C-terminal residue is blocked by a leaving group. It enables both synthesis of C-terminal protected peptides that are useful for convergent synthesis of large peptides and use of a C-terminal permanent protecting group that can be cleaved by catalytic hydrogenation to release the peptide.

引用

页码：2313 / 2315

页数：3

共 27 条

[21] Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery [J].