Metastatic Colorectal Cancer: Prognostic and Predictive Factors

被引：16

作者：

Nappi, Anna ^{[1
]}

Nasti, Guglielmo ^{[2
]}

Romano, Carmela ^{[1
]}

Berretta, Assimiliano ^{[3
]}

Ottaiano, Alessandro ^{[2
]}

机构：

[1] Ist Nazl Tumori Napoli, IRCCS G Pascale, Natl Canc Inst, Abdominal Med Oncol, Naples, Italy

[2] Ist Nazl Tumori Napoli, IRCCS G Pascale, SSD Innovat Therapies Abdominal Metastases, Naples, Italy

[3] Natl Canc Inst CRO, Dept Med Oncol, Aviano, PN, Italy

来源：

CURRENT MEDICINAL CHEMISTRY | 2020年 / 27卷 / 17期

关键词：

Colorectal cancer; metastases; prognostic factors; predictive factors; biologic therapy; chemotherapy; KRAS WILD-TYPE; TUMOR MUTATIONAL BURDEN; GROWTH-FACTOR RECEPTOR; BODY-MASS INDEX; 1ST-LINE TREATMENT; MICROSATELLITE INSTABILITY; COLON-CANCER; ACQUIRED-RESISTANCE; PTEN EXPRESSION; MSI-H;

D O I：

10.2174/0929867326666190620110732

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Colorectal cancer represents the third most frequently occurring cancer worldwide. In the last decade, the survival of patients affected by metastatic colorectal cancer (mCRC) has improved through the introduction of biological drugs. However, in this new and dynamic therapeutic context, research about prognostic and predictive factors is important to guide the oncologists to effective therapies as well as to improve the understanding of colorectal cancer biology. Their identification is an intensive area of research and our future goal will be to depict tumour-specific "molecular signatures" in order to predict the clinical course of the disease and the best treatments. In this report, we describe clinical, pathological and molecular biomarkers that can play a role as prognostic or predictive factors in mCRC.

引用

页码：2779 / 2791

页数：13

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