Concomitant endometrial and cervical adenocarcinoma A case report and literature review

Rationale: Concomitant malignancy of the endometrium and cervix is extremely rare. Patient concerns: A 56-year-old female presented to the Women's Hospital, School of Medicine, Zhejiang University, complaining of irregular vaginal bleeding. The human papillomavirus test (type 18/45) was positive. We performed dilation and curettage; pathology revealed moderately differentiated endometrial carcinoma exhibiting squamous differentiation. The epithelium of the cervical uterus was atypical upon biopsy. Diagnoses: Histological and immunochemical tests confirmed a diagnosis of endometrial carcinoma concomitant with cervical adenocarcinoma. Interventions: She underwent laparoscopic staging surgery. Outcomes: The patient fully recovered with only surgery. Lessons: Endometrial carcinoma concomitant with cervical adenocarcinoma is very rare. It is imperative to schedule adequate examination, and to perform careful preoperative diagnosis and appropriate treatment to minimize relapse.