Tau Abnormalities and the Potential Therapy in Alzheimer's Disease

被引：26

作者：

Almansoub, Hasan A. M. M. ^{[1
,2
,3
]}

Tang, Hui ^{[1
,2
]}

Wu, Ying ^{[1
,2
]}

Wang, Ding-Qi ^{[1
,2
]}

Mahaman, Yacoubou Abdoul Razak ^{[1
,2
]}

Wei, Na ^{[4
,5
]}

Almansob, Yusra A. M. ^{[6
]}

He, Wei ^{[7
]}

Liu, Dan ^{[2
,8
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Key Lab Neurol Disorder, Educ Minist,Dept Pathophysiol,Sch Basic Med, Wuhan, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Collaborat Innovat Ctr Brain Sci, Inst Brain Res, Wuhan, Hubei, Peoples R China

[3] Sanaa Univ, Fac Sci Marib, Dept Biol, Marib, Yemen

[4] Zhengzhou Univ, Affiliated Hosp 1, Dept Pathol, Zhengzhou, Henan, Peoples R China

[5] Zhengzhou Univ, Sch Basic Med, Dept Pathol, Zhengzhou, Henan, Peoples R China

[6] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Stomatol, Wuhan, Hubei, Peoples R China

[7] Hubei Hosp Tradit Chinese Med, Dept Orthoped, Wuhan, Hubei, Peoples R China

[8] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Genet, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2019年 / 67卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Aggregation; Alzheimer's disease; hyperphosphorylation; post-translational modifications; tau; PAIRED HELICAL FILAMENTS; AMYLOID PLAQUE-FORMATION; PROTEIN-TAU; NEUROFIBRILLARY TANGLES; MOUSE MODEL; IN-VITRO; CONFORMATIONAL-CHANGES; ACETYLATED TAU; FRONTOTEMPORAL DEMENTIA; ABERRANT GLYCOSYLATION;

D O I：

10.3233/JAD-180868

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases that is characterized by progressive memory loss and two main pathological hallmarks, including the extracellular amyloid plaques and intracellular neurofibrillary tangles. The microtubule-related protein tau is involved in the pathogenesis of many neurological diseases commonly known as tauopathies and is found to be abnormally hyperphosphorylated in AD and accumulated in neurons. Besides hyperphosphorylation, tau also undergoes abnormal glycosylation, ubiquitination, glycation, and other posttranslational modifications. These abnormalities lead to the aberrant aggregation of tau in the synaptic loci in AD. In this review, we highlighted the most recent studies about how tau is abnormally regulated and how those abnormalities play important roles in the pathogenesis of AD.

引用

页码：13 / 33

页数：21

共 211 条

[1] MicroRNAs and neurodegeneration: role and impact [J].