Curcumin attenuates myocardial ischemia-reperfusion injury

被引：26
作者：
Liu, Kun [1 ]
Chen, Honglin [2 ]
You, Qing-Sheng [1 ]
Ye, Qing [3 ]
Wang, Fei [1 ]
Wang, Shuo [1 ]
Zhang, Shuang-Long [1 ]
Yu, Kang-Jun [1 ]
Lu, Qi [4 ]
机构：
[1] Nantong Univ, Affiliated Hosp, Dept Cardiothorac Surg, Nantong, Peoples R China
[2] Nantong Univ, Sch Nursing, Nantong, Peoples R China
[3] Nantong Univ, Affiliated Hosp, Dept Obstet & Gynecol, Nantong, Peoples R China
[4] Nantong Univ, Affiliated Hosp, Dept Cardiol, Nantong, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 67期
基金：
中国博士后科学基金;
关键词：
curcumin; myocardial ischemia-reperfusion; inflammation; ACUTE LUNG INJURY; RATS; KINASE; SALIDROSIDE; PATHWAY; INFLAMMATION; INHIBITION; MICE;
D O I：
10.18632/oncotarget.23002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Cardiovascular diseases (CVDs) are at a badly high-risk of morbidity and mortality in the world. Methods: Our study was attempted to investigate the cardioprotective role of curcumin. Hearts injury was assessed in isolated hearts and the rats of coronary artery ligated. Results and Conclusions: The inhibition of pro-inflammatory cytokines was observed by curcumin in coronary artery ligated rats. ST segment was also reduced by curcumin. Triphenyltetrazolium chloride staining (TTC) staining and pathological analysis were also showed that curcumin could dramatically alleviate myocardial injury. Besides, the results in vitro also demonstrated that curcumin could improved the function of isolated hearts. Besides, the expressions of inflammation-related pathway in both rats and isolated hearts treated with curcumin were significantly decreased. The present study investigated the protective effects of curcumin on myocardial injury and its mechanism.
引用
收藏
页码：112051 / 112059
页数：9
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