Free estradiol and sex hormone-binding globulin

被引:26
作者
Rosner, William [1 ]
机构
[1] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA
关键词
SHBG; Free estradiol; Free testosterone; Assay; Estradiol; CENTRIFUGAL ULTRAFILTRATION-DIALYSIS; FREE TESTOSTERONE; HUMAN-PLASMA; SERUM; WOMEN;
D O I
10.1016/j.steroids.2014.08.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
SHBG is a plasma protein that participates in the regulation of free estradiol and free testosterone in plasma. We discuss the concept of the nature of a free estradiol and how best to ascertain its value. It can be measured or calculated; the ways in which this can be done are explored along with the advantages and disadvantages of each. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:113 / 116
页数:4
相关论文
共 27 条
[21]   CALCULATION OF FREE AND BOUND FRACTIONS OF TESTOSTERONE AND ESTRADIOL-17BETA- TO HUMAN-PLASMA PROTEINS AT BODY-TEMPERATURE [J].
SODERGARD, R ;
BACKSTROM, T ;
SHANBHAG, V ;
CARSTENSEN, H .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1982, 16 (06) :801-810
[22]   Steroid binding properties of the 2nd WHO International Standard for sex hormone-binding globulin [J].
Thaler, Markus ;
Mueller, Carolin ;
Schlichtiger, Alice ;
Gruendler, Katharina ;
Moore, Melanie ;
Luppa, Peter B. .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2011, 49 (05) :869-872
[23]  
Van UK, 2004, CLIN CHEM, V50, P2101
[24]   Immunological and Mass Spectrometric Assays of SHBG: Consistent and Inconsistent Metabolic Associations in Healthy Men [J].
Veldhuis, Johannes D. ;
Bondar, Olga P. ;
Dyer, Roy B. ;
Trushin, Sergey A. ;
Klee, Eric W. ;
Singh, Ravinder J. ;
Klee, George G. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2014, 99 (01) :184-193
[25]   A critical evaluation of simple methods for the estimation of free testosterone in serum [J].
Vermeulen, A ;
Verdonck, L ;
Kaufman, JM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (10) :3666-3672
[26]   APPARENT FREE TESTOSTERONE CONCENTRATION, AN INDEX OF ANDROGENICITY [J].
VERMEULEN, A ;
STOICA, T ;
VERDONCK, L .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1971, 33 (05) :759-+
[27]  
Zakharov MN, MOL CELL EN IN PRESS