Inclusion body myositis associated with hepatitis C virus infection

被引：13

作者：

Kase, S ^{[1
]}

Shiota, G

Fujii, Y

Okamoto, K

Oyama, K

Nakano, T

Nomura, T

Suou, T

Nakashima, K

Ito, H

Kawasaki, H

机构：

[1] Tottori Univ, Fac Med, Dept Pathol 1, Yonago, Tottori 6838504, Japan

[2] Tottori Univ, Fac Med, Dept Internal Med 2, Yonago, Tottori 6838504, Japan

[3] Tottori Univ, Fac Med, Inst Neurol Sci, Div Neurol, Yonago, Tottori 683, Japan

来源：

LIVER | 2001年 / 21卷 / 05期

关键词：

hepatitis C virus; inclusion body myositis; 8-hydroxy-2 '-deoxy-guanosine;

D O I：

10.1034/j.1600-0676.2001.210509.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The case of a 77-year-old woman with hepatitis C virus infection with a 5-year history of muscle weakness and mild disturbance of gait is reported. Steroid therapy did not improve her symptoms. She developed HCV-related liver cirrhosis and hepatocellular carcinoma, and muscle 2 biopsy revealed inclusion body myositis. Immunohistochemistry showed that the nonstructural region of HCV and 8-hydroxy-2 ' -deoxyguanosine, a of marker of DNA damage by reactive oxygen species, were present in striated muscle cells of this patient.

引用

页码：357 / 360

页数：4

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