Antileishmanial physalins from Physalis minima

被引：48

作者：

Choudhary, MQ ^{[1
]}

Yousaf, S ^{[1
]}

Ahmed, S ^{[1
]}

Samreen ^{[1
]}

Yasmeen, K ^{[1
]}

Atta-ur-Rahman ^{[1
]}

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan

来源：

CHEMISTRY & BIODIVERSITY | 2005年 / 2卷 / 09期

关键词：

D O I：

10.1002/cbdv.200590086

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new physalins (1-3) and a new withanolide 7 have been isolated from the whole plant of Physalis mininia, along with three known physalins: physalin H (4), isophysalin B (5), and 5 beta,6 beta-epoxyphysalin B (6). Their structures were deduced on the basis of in-depth spectroscopic analyses. Compounds 1-6 showed significant in vitro leishmanicidal activities (0.92-19.4 mu g/ml) against promastigotes of Leishmania major.

引用

页码：1164 / 1173

页数：10

共 29 条

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