A three-component reaction of phosphorus ylides with isocyanates: facile synthesis of 2-amino-3-carboxylate-4-quinolones

被引：13

作者：

Babu, Kaki Raveendra ^{[1
,2
]}

Han, Wendan ^{[1
,2
]}

Chen, Jian-Bo ^{[3
]}

Li, Yang ^{[1
,2
]}

Tang, Yuhai ^{[1
,2
]}

Zhang, Wenquan ^{[3
]}

Xu, Wenbo ^{[4
]}

Xu, Silong ^{[1
,2
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Sci, Dept Chem, Xian 710049, Peoples R China

[2] Xi An Jiao Tong Univ, Xian Key Lab Sustainable Energy Mat Chem, Xian 710049, Peoples R China

[3] China Acad Engn Phys, Inst Chem Mat, Mianyang 621900, Sichuan, Peoples R China

[4] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 44期

基金：

中国国家自然科学基金;

关键词：

ALLYLIC ALKYLATION; 4-QUINOLONES; ROUTE; ACIDS; OLEFINATION; CYCLIZATION; ALLYLATION; INHIBITORS; CARBONATES; ANILINES;

D O I：

10.1039/d0cc01401j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A three-component reaction between one molecule of phosphorus ylides (P-ylides) and two molecules of isocyanates for the rapid assembly of 2-amino-3-carboxylate-4-quinolones is described. The mechanism may involve the addition of a P-ylide to an isocyanate followed by 1,3-H shift to form a carbamoyl stabilized P-ylide. The intermediate then reacts with another aryl isocyanate via Wittig/ketenimine-ketene rearrangement/6 pi-electrocyclization/1,3-H shift to finally afford the 4-quinolones.

引用

页码：5909 / 5912

页数：4

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