Cortical thickness atrophy in the transentorhinal cortex in mild cognitive impairment

被引：33

作者：

Kulason, Sue ^{[1
,2
,3
]}

Tward, Daniel J. ^{[1
,2
,3
,4
]}

Brown, Timothy ^{[1
,2
]}

Sicat, Chelsea S. ^{[1
,2
]}

Liu, Chin-Fu ^{[1
,2
,3
]}

Ratnanather, J. Tilak ^{[1
,2
,3
]}

Younes, Laurent ^{[1
,2
,5
]}

Bakker, Arnold ^{[6
]}

Gallagher, Michela ^{[7
]}

Albert, Marilyn ^{[8
]}

Miller, Michael I. ^{[1
,2
,3
,4
]}

Weiner, Michael W. ^{[9
,93
]}

Aisen, Paul ^{[10
]}

Weiner, Michael ^{[9
]}

Petersen, Ronald ^{[11
]}

Jack, Clifford R., Jr. ^{[11
]}

Jagust, William ^{[12
,93
]}

Trojanowki, John Q. ^{[13
,39
,94
,95
]}

Toga, Arthur W. ^{[10
,14
]}

Beckett, Laurel ^{[15
]}

Green, Robert C. ^{[16
,30
]}

Saykin, Andrew J. ^{[17
]}

Morris, John ^{[18
]}

Shaw, Leslie M. ^{[13
,39
,94
]}

Khachaturian, Zaven ^{[19
]}

Sorensen, Greg ^{[20
]}

Carrillo, Maria ^{[21
]}

Kuller, Lew ^{[22
]}

Raichle, Marc ^{[18
]}

Paul, Steven ^{[23
]}

Davies, Peter ^{[24
]}

Fillit, Howard ^{[25
]}

Hefti, Franz ^{[26
]}

Holtzman, David ^{[18
]}

Mesulam, M. Marcel ^{[27
]}

Potter, William ^{[28
]}

Snyder, Peter ^{[29
]}

Lilly, Eli

Logovinsky, Veronika

Montine, Tom ^{[18
,31
]}

Jimenez, Gustavo ^{[14
]}

Donohue, Michael ^{[14
,32
]}

Gessert, Devon ^{[14
]}

Harless, Kelly ^{[14
]}

Salazar, Jennifer ^{[14
]}

Cabrera, Yuliana ^{[14
]}

Walter, Sarah ^{[14
]}

Hergesheimer, Lindsey ^{[14
]}

Harvey, Danielle

Jack, Clifford R., Jr. ^{[11
]}

机构：

[1] Johns Hopkins Univ, Ctr Imaging Sci, 601 Elmwood Ave, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Inst Computat Med, Baltimore, MD 21218 USA

[3] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Kavli Neurosci Discovery Inst, Baltimore, MD 21218 USA

[5] Johns Hopkins Univ, Dept Appl Math & Stat, Baltimore, MD 21218 USA

[6] Johns Hopkins Univ, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[7] Johns Hopkins Sch Arts & Sci, Dept Psychol & Brain Sci, Baltimore, MD 21218 USA

[8] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21205 USA

[9] UC San Francisco, San Francisco, CA USA

[10] Univ Southern Calif, Los Angeles, CA 90089 USA

[11] Mayo Clin, Rochester, MN USA

[12] Univ Calif Berkeley, Berkeley, CA USA

[13] Univ Penn, Philadelphia, PA 19104 USA

[14] USC, Los Angeles, CA USA

[15] Univ Calif Davis, Davis, CA USA

[16] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA USA

[17] Indiana Univ, Bloomington, IN 47405 USA

[18] Washington Univ, St Louis, MO 63130 USA

[19] Prevent Alzheimers Dis 2020, Rockville, MD USA

[20] Siemens, Munich, Germany

[21] Alzheimers Assoc, Chicago, IL USA

[22] Univ Pittsburgh, Pittsburgh, PA 15260 USA

[23] Cornell Univ, Ithaca, NY 14853 USA

[24] Yeshiva Univ, Albert Einstein Col Med, New York, NY 10033 USA

[25] AD Drug Discovery Fdn, New York, NY USA

[26] Acumen Pharmceut, Livermore, CA USA

[27] Northwestern Univ, Evanston, IL 60208 USA

[28] NIMH, Rockville, MD 20852 USA

[29] Brown Univ, Providence, RI 02912 USA

[30] HMS, BWH, Boston, MA USA

[31] Univ Washington, Seattle, WA 98195 USA

[32] Univ Calif San Diego, La Jolla, CA USA

[33] Univ London, London, England

[34] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90024 USA

[35] UCSF, MRI, San Francisco, CA USA

[36] Univ Michigan, Ann Arbor, MI 48109 USA

[37] Univ Utah, Salt Lake City, UT 84112 USA

[38] Banner Alzheimers Inst, Phoenix, AZ USA

[39] UPenn Sch Med, Philadelphia, PA USA

[40] UC Irvine, Irvine, CA USA

[41] NIA, Bethesda, MD 20892 USA

[42] Johns Hopkins Univ, Baltimore, MD 21218 USA

[43] Richard Frank Consulting, Sacramento, CA USA

[44] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

[45] Univ Calif San Diego, La Jolla, CA 92093 USA

[46] Baylor Coll Med, Houston, TX 77030 USA

[47] Columbia Univ, Med Ctr, New York, NY 10027 USA

[48] Univ Alabama Birmingham, Birmingham, AL USA

[49] Mt Sinai Sch Med, New York, NY USA

[50] Rush Univ, Med Ctr, Chicago, IL 60612 USA

来源：

NEUROIMAGE-CLINICAL | 2019年 / 21卷

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

Entorhinal cortex; Transentorhinal cortex; Mild cognitive impairment; Braak staging; Cortical thickness; Shape analysis; Longitudinal analysis; ALZHEIMERS ASSOCIATION WORKGROUPS; ENTORHINAL CORTEX; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; HIPPOCAMPAL; DISEASE; MEMORY; DIFFEOMORPHOMETRY; MORPHOMETRY; VOLUME;

D O I：

10.1016/j.nicl.2018.101617

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

This study examines the atrophy rates of subjects with mild cognitive impairment (MCI) compared to controls in four regions within the medial temporal lobe: the transentorhinal cortex (TEC), entorhinal cortex (ERC), hippocampus, and amygdala. These regions were manually segmented and then corrected for undesirable longitudinal variability via Large Deformation Diffeomorphic Metric Mapping (LDDMM) based longitudinal diffeomorphometry. Diffeomorphometry techniques were used to compare thickness measurements in the TEC with the ERC. There were more significant changes in thickness atrophy rate in the TEC than medial regions of the entorhinal cortex. Volume measures were also calculated for all four regions. Classifiers were constructed using linear discriminant analysis to demonstrate that average thickness and atrophy rate of TEC together was the most discriminating measure compared to the thickness and volume measures in the areas examined, in differentiating MCI from controls. These findings are consistent with autopsy findings demonstrating that initial neuronal changes are found in TEC before spreading more medially in the ERC and to other regions in the medial temporal lobe. These findings suggest that the TEC thickness could serve as a biomarker for Alzheimer's disease in the prodromal phase of the disease.

引用

页数：10

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