Serum α- and γ-tocopherol concentrations and risk of advanced beta cell autoimmunity in children with HLA-conferred susceptibility to type 1 diabetes mellitus

被引：20

作者：

Uusitalo, L. ^{[1
,2
]}

Nevalainen, J. ^{[1
,2
]}

Niinisto, S. ^{[3
]}

Alfthan, G. ^{[4
]}

Sundvall, J. ^{[4
]}

Korhonen, T. ^{[1
]}

Kenward, M. G. ^{[5
]}

Oja, H. ^{[2
]}

Veijola, R. ^{[6
]}

Simell, O. ^{[7
,8
,9
,10
]}

Ilonen, J. ^{[11
,12
]}

Knip, M. ^{[8
,9
,10
,13
,14
]}

Virtanen, S. M. ^{[1
,2
,15
]}

机构：

[1] Natl Publ Hlth Inst, Dept Hlth Promot & Chron Dis Prevent, SF-00300 Helsinki, Finland

[2] Univ Tampere, Tampere Sch Publ Hlth, FIN-33101 Tampere, Finland

[3] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland

[4] Natl Publ Hlth Inst, Dept Hlth & Funct Capac, SF-00300 Helsinki, Finland

[5] London Sch Hyg & Trop Med, Med Stat Unit, Dept Epidemiol & Populat Hlth, London WC1, England

[6] Univ Oulu, Dept Pediat, SF-90100 Oulu, Finland

[7] Univ Turku, Dept Pediat, Turku, Finland

[8] Juvenile Diabet Res Fdn Ctr Prevent Type 1 Diabet, Turku, Finland

[9] Juvenile Diabet Res Fdn Ctr Prevent Type 1 Diabet, Oulu, Finland

[10] Juvenile Diabet Res Fdn Ctr Prevent Type 1 Diabet, Tampere, Finland

[11] Univ Kuopio, Dept Clin Microbiol, FIN-70211 Kuopio, Finland

[12] Univ Turku, Immunogenet Lab, Turku, Finland

[13] Tampere Univ Hosp, Dept Pediat, Tampere, Finland

[14] Univ Helsinki, Hosp Children & Adolescents, Helsinki, Finland

[15] Tampere Univ Hosp, Res Unit, Tampere, Finland

来源：

DIABETOLOGIA | 2008年 / 51卷 / 05期

基金：

芬兰科学院;

关键词：

aetiology; beta cell autoimmunity; children; cholesterol; alpha-tocopherol; gamma-tocopherol; type; 1; diabetes; vitamin E;

D O I：

10.1007/s00125-008-0959-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims/hypothesis The aim of our study was to assess the associations of serum alpha- and gamma-tocopherol concentrations with the risk of advanced beta cell autoimmunity in children with HLA-conferred genetic susceptibility to type 1 diabetes mellitus. Methods A case-control study with 108 cases with advanced beta cell autoimmunity and 216 matched control participants nested within the birth cohort of the Type 1 Diabetes Prediction and Prevention Project. A serum sample for vitamin E analyses was collected from all the children in the cohort at the age of 1 year and thereafter at 12 month intervals. For each case-control group, all the repeated serum samples up to the age of seroconversion to autoantibody positivity in the case were analysed. A conditional logistic regression model was used to determine potential associations between seroconversion and serum tocopherol concentrations. Results Serum alpha- or gamma-tocopherol concentrations were not significantly associated with the risk of advanced beta cell autoimmunity. The odds ratio (95% CI) for mu mol/l increase in serum concentration of the first-year sample was 0.97 (0.92-1.03) for alpha-tocopherol and 1.10 (0.70-1.74) for gamma-tocopherol. However, there was an interaction between high values of gamma-tocopherol at the age of 1 year and the time of seroconversion (p=0.024). Conclusions/Interpretation It seems unlikely that high concentrations of alpha- or gamma-tocopherol protect against advanced beta cell autoimmunity in young children.

引用

页码：773 / 780

页数：8

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