Skin biopsy-proven flecainide-induced neuropathy

被引:7
|
作者
Burakgazi, Ahmet Z. [2 ]
Polydefkis, Michael [1 ]
Hoeke, Ahmet [1 ]
机构
[1] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[2] George Washington Univ, Dept Neurol, Washington, DC USA
关键词
flecainide; peripheral neuropathy; skin biopsy; toxic neuropathy; potassium channel; PARANOID PSYCHOSIS; TOXICITY; NEURONS; CHANNEL;
D O I
10.1002/mus.22239
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Flecainide acetate is a classic Ic antiarrhythmic agent used to treat a variety of cardiac arrhythmias. Non-cardiac side effects usually affect the central nervous system. Few case reports of possible flecainide-induced peripheral neuropathy have been reported. We report this unique case in that flecainide-induced sensory neuropathy was confirmed with skin biopsy, and subsequent improvement of neuropathy was documented with assessment of intraepidermal nerve fiber density in a repeat nerve biopsy. Muscle Nerve 45: 144146, 2011
引用
收藏
页码:144 / 146
页数:3
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