Clinical value of serum VEGF and sFlt-1 in pernicious placenta previa

被引：24

作者：

Wang, Na ^{[1
]}

Shi, Dandan ^{[1
]}

Li, Na ^{[1
]}

Qi, Hongyuan ^{[1
]}

机构：

[1] Cangzhou Cent Hosp, Obstet Dept, 16 Xinhua Western Rd, Cangzhou 061000, Peoples R China

来源：

ANNALS OF MEDICINE | 2021年 / 53卷 / 01期

关键词：

VEGF; sFlt-1; pernicious placenta previa; placenta accreta; placenta increta; ACCRETA; GROWTH;

D O I：

10.1080/07853890.2021.1999492

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study was designed to explore the expression and the diagnostic value of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in pernicious placenta previa (PPP) combined placental accreta/increta. A total of 140 PPP patients were enrolled and divided into two groups: 56 patients with placenta accreta/increta (PA group), and 84 patients without placenta accreta/increta (non-PA group). In the same period, 46 pregnant women without PPP who had undergone caesarean section were selected as controls. The levels of VEGF and sFlt-1 in serum were detected by enzyme-linked immunosorbent assay. Diagnostic efficiency of VEGF and sFlt-1 in serum were evaluated by receiver operating characteristics curve. It was found that both VEGF and sFlt-1 had diagnostic value for PPP and placenta accreta/increta combined PPP. In addition, the levels of VEGF and sFlt-1 could be used to distinguish placenta accreta from placenta increta. VEGF was negatively correlated with sFlt-1 in PPP patients. In summary, the levels of VEGF and sFlt-1 could be used as auxiliary indicators to diagnose PPP and distinguish between placenta accreta and increta.

引用

页码：2041 / 2049

页数：9

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