Chromosome 1p loss:: A favorable prognostic factor in low-grade gliomas

被引：68

作者：

Kujas, M

Lejeune, J

Benouaich-Amiel, A

Crinière, E

Laigle-Donadey, F

Marie, Y

Mokhtari, K

Polivka, M

Bernier, M

Chretien, F

Couvelard, A

Capelle, L

Duffau, H

Cornu, P

Broët, P

Thillet, J

Carpentier, AF

Sanson, M

Hoang-Xuan, K

Delattre, JY

机构：

[1] INSERM, U711, F-75654 Paris, France

[2] Univ Paris 06, F-75252 Paris, France

[3] Grp Hosp Pitie Salpetriere, APHP, Lab Neuropathol R Escourolle, Paris, France

[4] Grp Hosp Pitie Salpetriere, Serv Neurol Mazarin, F-75634 Paris, France

[5] Hop Lariboisiere, Serv Anatomopathol, F-75475 Paris, France

[6] Hop Foch, Serv Anatomopathol, Suresnes, France

[7] Hop Henri Mondor, Serv Anatomopathol, F-94010 Creteil, France

[8] Hop Beaujon, Serv Anatomopathol, Clichy, France

[9] Grp Hosp Pitie Salpetriere, Serv Neurochirurg, F-75634 Paris, France

[10] Hop Paul Brousse, INSERM, U472, Villejuif, France

来源：

ANNALS OF NEUROLOGY | 2005年 / 58卷 / 02期

关键词：

D O I：

10.1002/ana.20543

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Search for loss of heterozygosity on chromosomes 1p, 9p, 10q, and 19q, epidermal growth factor receptor (EGFR) gene amplification, and p53 expression was performed in a series of 131 low-grade gliomas. The profile of molecular changes, clinical findings, and histology were subsequently correlated with the course of the disease, mainly progression-free survival. When these parameters were considered as candidate variables in a multivariate analysis, only loss of heterozygosity on chromosome 1p was associated with increased progression-free survival (hazard ratio, 0.521), indicating a major favorable prognostic role of this genetic alteration in low-grade gliomas.

引用

页码：322 / 326

页数：5

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