Co9Se8 Nanoplates as a New Theranostic Platform for Photoacoustic/Magnetic Resonance Dual-Modal-Imaging-Guided Chemo-Photothermal Combination Therapy

被引：262
作者：
Song, Xiao-Rong [1 ]
Wang, Xiaoyong [2 ]
Yu, Shu-Xian [1 ]
Cao, Jianbo [2 ]
Li, Shi-Hua [1 ]
Li, Juan [1 ]
Liu, Gang [2 ]
Yang, Huang-Hao [1 ]
Chen, Xiaoyuan [3 ]
机构：
[1] Fuzhou Univ, Coll Chem, Key Lab Anal & Detect Technol Food Safety, MOE,State Key Lab Photocatalysis Energy & Environ, Fuzhou 350108, Peoples R China
[2] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361005, Peoples R China
[3] NIBIB, LOMIN, NIH, Bethesda, MD 20892 USA
来源：
ADVANCED MATERIALS | 2015年 / 27卷 / 21期
基金：
美国国家科学基金会; 中国国家自然科学基金;
关键词：
chemotherapy; magnetic resonance imaging; nanoplates; photoacoustic imaging; photothermal therapy; COBALT NANOPARTICLES; MESOPOROUS SILICA; CARBON NANOTUBES; IRON-OXIDE; CANCER; NANOSHEETS; EFFICIENT; AGENTS; MRI; CONSTRUCTION;
D O I：
10.1002/adma.201405634
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new theranostic platform is developed based on biocompatible poly(acrylic acid) (PAA)-Co9 Se8 nanoplates. These PAA-Co9 Se8 nanoplates are successfully utilized for photoacoustic imaging (PAI)/magnetic resonance imaging (MRI) dual-modal imaging. Moreover, the PAA-Co9 Se8-DOX shows pH-responsive chemotherapy and enables the combination of photothermal therapy and chemotherapy to receive superior antitumor efficacy. This work promises further exploration of 2D nanoplatforms for theranostic applications. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：3285 / 3291
页数：7
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