The role of exosomes in intercellular and inter-organ communication of the peripheral nervous system

被引:35
作者
Bischoff, Julia Patricia [1 ]
Schulz, Alexander [1 ]
Morrison, Helen [1 ,2 ,3 ]
机构
[1] Fritz Lipmann Inst, Leibniz Inst Aging, Beutenbergstr 11, D-07745 Jena, Germany
[2] Friedrich Schiller Univ Jena, Inst Biochem & Biophys, Jena, Germany
[3] Friedrich Schiller Univ Jena, Fac Biol Sci, Jena, Germany
关键词
exosome; homeostasis; intercellular communication; PNS; regeneration; AXONAL PROTEIN-SYNTHESIS; CELL-DERIVED EXOSOMES; SCHWANN-CELL; EXTRACELLULAR VESICLES; REPAIR PHENOTYPE; REGENERATION; MECHANISMS; SECRETION; INSIGHTS; BRAIN;
D O I
10.1002/1873-3468.14274
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Exosomes, nano-sized extracellular vesicles, are produced via the endosomal pathway and released in the extracellular space upon fusion of multivesicular bodies with the plasma membrane. Recent evidence shows that these extracellular vesicles play a key role in cell-to-cell communication. Exosomes transport bioactive proteins, mRNAs, and microRNA (miRNAs) in an active form to adjacent cells or to distant organs. In this review, we focus on the role of exosomes in peripheral nerve maintenance and repair, as well as peripheral nerve/organ crosstalk, and discuss the potential benefits of exploiting exosomes for treating PNS injuries. In addition, we will highlight the emerging role of exosomes as new important vehicles for physiological systemic crosstalk failures, which could lead to organ dysfunction during neuroinflammation or aging.
引用
收藏
页码:655 / 664
页数:10
相关论文
共 99 条
[51]   Exosomes and Their Role in Cancer Progression [J].
Osaki, Mitsuhiko ;
Okada, Futoshi .
YONAGO ACTA MEDICA, 2019, 62 (02) :182-190
[52]   Cell-to-cell Communication by Extracellular Vesicles: Focus on Microglia [J].
Paolicelli, Rosa C. ;
Bergamini, Giorgio ;
Rajendran, Lawrence .
NEUROSCIENCE, 2019, 405 :148-157
[53]   EphB Signaling Directs Peripheral Nerve Regeneration through Sox2-Dependent Schwann Cell Sorting [J].
Parrinello, Simona ;
Napoli, Ilaria ;
Ribeiro, Sara ;
Digby, Patrick Wingfield ;
Fedorova, Marina ;
Parkinson, David B. ;
Doddrell, Robin D. S. ;
Nakayama, Masanori ;
Adams, Ralf H. ;
Lloyd, Alison C. .
CELL, 2010, 143 (01) :145-155
[54]  
Perbal B., 2003, CELL COMMUN SIGNAL, V1, P1, DOI [10.1186/1478-811X-1-3, DOI 10.1186/1478-811X-1-3]
[55]   Dicer in Schwann Cells Is Required for Myelination and Axonal Integrity [J].
Pereira, Jorge A. ;
Baumann, Reto ;
Norrmen, Camilla ;
Somandin, Christian ;
Miehe, Michaela ;
Jacob, Claire ;
Luehmann, Tessa ;
Hall-Bozic, Heike ;
Mantei, Ned ;
Meijer, Dies ;
Suter, Ueli .
JOURNAL OF NEUROSCIENCE, 2010, 30 (19) :6763-6775
[56]   Exosome-based immunomodulation during aging: A nano-perspective on inflamm-aging [J].
Prattichizzo, Francesco ;
Micolucci, Luigina ;
Cricca, Monica ;
De Carolis, Sabrina ;
Mensa, Emanuela ;
Ceriello, Antonio ;
Procopio, Antonio Domenico ;
Bonafe, Massimiliano ;
Olivieri, Fabiola .
MECHANISMS OF AGEING AND DEVELOPMENT, 2017, 168 :44-53
[57]   Exosomes: the future of biomarkers in medicine [J].
Properzi, Francesca ;
Logozzi, Mariantonia ;
Fais, Stefano .
BIOMARKERS IN MEDICINE, 2013, 7 (05) :769-778
[58]   Environmental Enrichment Stimulates Immune Cell Secretion of Exosomes that Promote CNS Myelination and May Regulate Inflammation [J].
Pusic, Kae M. ;
Pusic, Aya D. ;
Kraig, Richard P. .
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2016, 36 (03) :313-325
[59]   Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation [J].
Qadir, Fatima ;
Aziz, Mohammad Arshad ;
Sari, Chrisdina Puspita ;
Ma, Hong ;
Dai, Haiyan ;
Wang, Xun ;
Raithatha, Dhiresh ;
Da Silva, Lucas Girotto Lagreca ;
Hussain, Muhammad ;
Poorkasreiy, Seyedeh P. ;
Hutchison, Lain L. ;
Waseem, Ahmad ;
Teh, Muy-Teck .
MOLECULAR CANCER, 2018, 17
[60]   The dynamic changes of main cell types in the microenvironment of sciatic nerves following sciatic nerve injury and the influence of let-7 on their distribution [J].
Qian, Tianmei ;
Wang, Pan ;
Chen, Qianqian ;
Yi, Sheng ;
Liu, Qianyan ;
Wang, Hongkui ;
Wang, Shiyuan ;
Geng, Wenqing ;
Liu, Zihao ;
Li, Shiying .
RSC ADVANCES, 2018, 8 (72) :41181-41191