Restoration of defective cross-presentation in tumors by gemcitabine

被引：20

作者：

McDonnell, Alison M. ^{[1
,2
]}

Lesterhuis, W. Joost ^{[1
,2
]}

Khong, Andrea ^{[1
,2
]}

Nowak, Anna K. ^{[1
,2
,3
]}

Lake, Richard A. ^{[1
,2
]}

Currie, Andrew J. ^{[1
,4
]}

Robinson, Bruce W. S. ^{[1
,2
]}

机构：

[1] Univ Western Australia, Sch Med & Pharmacol, Nedlands, WA 6009, Australia

[2] Natl Ctr Asbestos Related Dis, Nedlands, WA, Australia

[3] Sir Charles Gairdner Hosp, Dept Med Oncol, Nedlands, WA, Australia

[4] Murdoch Univ, Sch Vet & Life Sci, Murdoch, WA 6150, Australia

来源：

ONCOIMMUNOLOGY | 2015年 / 4卷 / 05期

关键词：

chemotherapy; cross-presentation; gemcitabine; tumor-infiltrating dendritic cells; T-CELLS; ANTIGEN;

D O I：

10.1080/2162402X.2015.1005501

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor antigen cross-presentation by dendritic cells (DCs) to specific CD8(+) T cells is central to antitumor immunity. Although highly efficient in draining lymph nodes, it is defective within the tumor site itself. Importantly, an immunogenic chemotherapy, gemcitabine, reverses this defect, allowing the potential re-stimulation of cytotoxic T lymphocytes within tumor sites.

引用

页数：2

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