Behavior of complex knots in single DNA molecules

被引：163

作者：

Bao, XR ^{[1
]}

Lee, HJ ^{[1
]}

Quake, SR ^{[1
]}

机构：

[1] CALTECH, Dept Appl Phys, Pasadena, CA 91125 USA

来源：

PHYSICAL REVIEW LETTERS | 2003年 / 91卷 / 26期

关键词：

D O I：

10.1103/PhysRevLett.91.265506

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We used optical tweezers to tie individual DNA molecules in knots. Although these knots become highly localized under tension, they remain surprisingly mobile and undergo thermal diffusion with classical random walk statistics. The diffusion constants of knots with different complexities correlate with theoretical calculations of knot sizes. We show that this correlation can be explained by a simple hydrodynamical model of "self-reptation" of the knot along a polymer.

引用

页数：4

共 26 条

[1] Tying a molecular knot with optical tweezers [J].