Synthesis of optically active 2,3-substituted-1,2,3,4-tetrahydro-4-quinolones using polyleucine

被引：32

作者：

Chen, WP

Egar, AL

Hursthouse, MB

Malik, KMA

Mathews, JE

Roberts, SM

机构：

[1] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

[2] Univ Wales Coll Cardiff, Dept Chem, EPSRC Xray Crystallog Serv, Cardiff CF1 3TB, S Glam, Wales

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 46期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(98)01249-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polyleucine catalyzes the asymmetric epoxidation of enone (1) in a non-aqueous medium to provide epoxy-ketones (2) and (3) (81 and 84% yields respectively; >98% ee). The epoxy-ketones (2) and (3) are subsequently cyclized to give 1,2,3,4-tetrahydro-4-quinolones (4) and (5) respectively, (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：8495 / 8498

页数：4

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