Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient

被引：62

作者：

Cubero, Maria ^{[1
,2
,3
]}

Esteban, Juan Ignacio ^{[1
,2
,3
]}

Otero, Teresa ^{[1
]}

Sauleda, Silvia ^{[3
,4
]}

Bes, Marta ^{[3
,4
]}

Esteban, Rafael ^{[1
,2
,3
]}

Guardia, Jaurne ^{[1
,2
,3
]}

Quer, Josep ^{[1
,2
,3
]}

机构：

[1] Hosp Univ Vall Hebron, Dept Internal Med, Liver Unit, Barcelona 08035, Spain

[2] Univ Autonoma Barcelona, UAB, Bellaterra, Spain

[3] Inst Salud Carlos III, CIBER Enfermedades Hepat & Digest CIBERRehd, Madrid, Spain

[4] Banc Sang Teixits, Inst Catala Salut, Barcelona, Spain

来源：

VIROLOGY | 2008年 / 370卷 / 02期

关键词：

HCV-NS3; inhibitor; mutant; resistant; untreated; patient;

D O I：

10.1016/j.virol.2007.10.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An increasing number of new hepatitis C virus NS3-protease inhibitors are being evaluated for the treatment of chronic hepatitis C. Treatment-induced selection of mutants conferring resistance to protease inhibitors has been shown both in vivo and in vitro. A specific mutation, A156T has been shown to confer high-level resistance to several such agents (BILN2061, VX-950, SCH446211 (SCH6) and SCH503034). Here we report the presence of the A156T mutation in close to 1% of NS3 sequences within the liver quasispecies of a chronic hepatitis C patient never treated with anti-NS3-protease inhibitors. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：237 / 245

页数：9

共 36 条

[1] Fidelity and mutational spectrum of Pfu DNA polymerase on a human mitochondrial DNA sequence [J].

Andre, P ;

Kim, A ;

Khrapko, K ;

Thilly, WG .

GENOME RESEARCH, 1997, 7 (08) :843-852

[2] Longitudinal evaluation of the structure of replicating and circulating hepatitis C virus quasispecies in nonprogressive chronic hepatitis C patients [J].

Cabot, B ;

Martell, M ;

Esteban, JI ;

Piron, M ;

Otero, T ;

Esteban, R ;

Guardia, J ;

Gómez, J .

JOURNAL OF VIROLOGY, 2001, 75 (24) :12005-12013

[3] Dynamics of hepatitis C virus replication in human liver [J].

Chang, M ;

Williams, O ;

Mittler, J ;

Quintanilla, A ;

Carithers, RL ;

Perkins, J ;

Corey, L ;

Gretch, DR .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (02) :433-444

[4] In situ distribution of hepatitis C virus replicative-intermediate RNA in hepatic tissue and its correlation with liver disease [J].

Chang, M ;

Marquardt, AP ;

Wood, BL ;

Williams, O ;

Cotler, SJ ;

Taylor, SL ;

Carithers, RL ;

Gretch, DR .

JOURNAL OF VIROLOGY, 2000, 74 (02) :944-955

[5] PCR fidelity of Pfu DNA polymerase and other thermostable DNA polymerases [J].

Cline, J ;

Braman, JC ;

Hogrefe, HH .

NUCLEIC ACIDS RESEARCH, 1996, 24 (18) :3546-3551

[6]

Domingo E, 1992, Genet Eng (N Y), V14, P13

[7]

Domingo E, 1989, Prog Drug Res, V33, P93

[8]

Domingo E, 1988, RNA GENETICS, P3

[9]

Domingo Esteban, 1994, P161

[10]

DUARTE EA, 1994, INFECT AGENT DIS, V3, P201

← 1 2 3 4 →