Synthesis of α-Aryl Nitriles through Palladium-Catalyzed Decarboxylative Coupling of Cyanoacetate Salts with Aryl Halides and Triflates

被引：205

作者：

Shang, Rui ^{[1
]}

Ji, Dong-Sheng ^{[1
]}

Chu, Ling ^{[2
]}

Fu, Yao ^{[2
]}

Liu, Lei ^{[1
]}

机构：

[1] Tsinghua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Dept Chem, Beijing 100084, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 19期

关键词：

arenes; cross-coupling; cyanonides; decarboxylation; palladium; CARBOXYLIC-ACIDS; C-H; POTASSIUM POLYFLUOROBENZOATES; AROMATIC CARBOXYLATES; DIRECT ARYLATION; BIARYL SYNTHESIS; BENZOIC-ACIDS; BROMIDES; ESTERS; CHLORIDES;

D O I：

10.1002/anie.201006763

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Worth its salt: The palladium-catalyzed decarboxylative coupling of the cyanoacetate salt as well as its mono- and disubstituted derivatives with aryl chlorides, bromides, and triflates is described (see scheme). This reaction is potentially useful for the preparation of a diverse array of α-aryl nitriles and has good functional group tolerance. S-Phos=2-(2,6- dimethoxybiphenyl)dicyclohexylphosphine), Xant-Phos=4,5-bis(diphenylphosphino)- 9,9-dimethylxanthene. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4470 / 4474

页数：5

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