A structural explanation for the twilight zone of protein sequence homology

被引：100
作者：
Chung, SY
Subbiah, S
机构：
[1] UNIFORMED SERV UNIV HLTH SCI,DEPT BIOCHEM,BETHESDA,MD 20814
[2] STANFORD UNIV,SCH MED,DEPT BIOL STRUCT,STANFORD,CA 94305
来源：
STRUCTURE | 1996年 / 4卷 / 10期
关键词：
D O I：
10.1016/S0969-2126(96)00119-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Homology modeling of protein structures as a function of sequence breaks down at the twilight zone limit of sequence identity between the template and target proteins. Our results suggest that protein sequences that have diverged from a common ancestor beyond the twilight zone may adopt side chain interactions that are very different from those endowed by the ancestral sequence.
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页码：1123 / 1127
页数：5
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